The Effect of Frequency and Duration of Breaks in Sitting Time on Metabolic Cardiovascular Risk Factors
BPS2
1 other identifier
interventional
14
1 country
1
Brief Summary
The primary aim of this study is to investigate the acute effect of the frequency and duration of breaks in sitting time on the metabolic risk factor profile.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Nov 2016
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 30, 2016
CompletedFirst Posted
Study publicly available on registry
November 1, 2016
CompletedStudy Start
First participant enrolled
November 1, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 15, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
July 15, 2018
CompletedDecember 14, 2018
December 1, 2018
1.7 years
October 30, 2016
December 12, 2018
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
AUC post prandial glucose concentration
6 hours
Secondary Outcomes (10)
AUC post prandial insulin concentration
6 hours
AUC post prandial c-peptide concentration
6 hours
AUC post prandial triglyceride concentration
6 hours
AUC post prandial total cholesterol concentration
6 hours
AUC post prandial ldl concentration
6 hours
- +5 more secondary outcomes
Study Arms (4)
Control
EXPERIMENTALParticipants will spend 8 hours sedentary. Sedentary time will be spent sitting in a chair, restricted to sedentary behaviors (working on a computer, reading, watching TV, etc.) Participants will only be allowed to stand or walk to go to the toilet.
Breaker
EXPERIMENTALParticipants will spend a total of 7 hours and 12 min sedentary and a total of 48 min breaking sitting time with LPA. Sedentary time will be done in bouts of 18 min with 2 min of light walking.
Intermediate
EXPERIMENTALTotal duration of sedentary time and LPA time will be the same as in Breaker. Sedentary time will be done in bouts of 54 min with 6 min of LPA between each bout.
Prolonger
EXPERIMENTALTotal duration of sedentary time and LPA time will be the same as in Breaker. Sedentary time will be done in bouts of 108 min with 12 min of LPA between each bout.
Interventions
Eligibility Criteria
You may qualify if:
- Males, age 20-50 years, waist-to-height ratio ≥ 0.5 and/or waist circumference ≥ 102 cm.
You may not qualify if:
- Clinically diagnosed diabetes, uncontrolled hypertension, use of glucose- and/or lipid-lowering medication, smoking, evidence of thyroid, liver, lung, heart or kidney disease, non-sedentary occupation, and VO2max levels above the considered average fitness according to age (Shvartz \& Reibold 1990), contraindications to increased levels of physical activity.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Center for Physical Activity Research, Copenhagen University Hospital
Copenhagen, 2100, Denmark
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Mathias Ried, PhD
Group leader
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- PREVENTION
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Group leader
Study Record Dates
First Submitted
October 30, 2016
First Posted
November 1, 2016
Study Start
November 1, 2016
Primary Completion
July 15, 2018
Study Completion
July 15, 2018
Last Updated
December 14, 2018
Record last verified: 2018-12