Neurological Changes With a Memory Self-efficacy Training Protocol

NCT04077320 | Completed

• 1 other identifier: BSCAN1920
• Study Type: interventional
• Target: 28
• Locations: 1 country
• Sites: 1

Brief Summary

Confidence in one's ability to accomplish a task, more formally known as self-efficacy, is an important psychological variable that can influence how the investigators perform on various tasks. Previous studies have shown that self-efficacy is a modifiable trait that can be improved and bolstered with training and practice. More importantly for this study, memory self-efficacy has been shown to be modifiable for older adults, consequently improving their performance on memory tasks. While there is evidence to support the importance of memory self-efficacy for successful memory performance in older adults, the underlying neurological changes that accompany these performance changes have not been explored. The goal of this study is to examine the changes in brain activity before and after a memory self-efficacy training program to better understand the mechanisms of both memory and self-efficacy.

Conditions

Mild Cognitive Impairment

Keywords

memory; older adults; randomized control trial; MRI; memory education

Outcome Measures

Primary Outcomes (2)

• Neurological bio-markers: Regional activation

  Using fMRI identify changes in activation patterns or signal change when performing an associative memory task

  Pre and Post intervention - 6 weeks

• Neurological bio-markers: Default mode network

  Using fMRI during a resting state observe changes in default mode network activation

  Pre and Post intervention - 6 weeks

Secondary Outcomes (7)

• Story Recall - Trained memory performance task

  Pre and Post intervention - 6 weeks

• List Recall - Trained memory performance tasks

  Pre and Post intervention - 6 weeks

• Face-Name Pairs - Trained memory performance tasks

  Pre and Post intervention - 6 weeks

• RAVLT - Untrained memory performance tasks

  Pre and Post intervention - 6 weeks

• Visual Spatial Learning Task - Untrained memory performance tasks

  Pre and Post intervention - 6 weeks

Other Outcomes (2)

• Memory self-efficacy: Multifactorial Memory Questionnaire (MMQ)

  Pre and Post intervention - 6 weeks

• Memory self-efficacy: Memory Self-efficacy Questionnaire (MSEQ) subjective scale

  Pre and Post intervention - 6 weeks

Study Arms (2)

Memory Self-Efficacy Training

EXPERIMENTAL

Memory self-efficacy group training classes.

Behavioral: Memory Self-Efficacy Training

General Education Group

ACTIVE COMPARATOR

General education group classes (e.g., exercise, diet, sustainability, tc.)

Behavioral: General Education

Interventions

Memory Self-Efficacy Training BEHAVIORAL

The intervention will consist of a six-week cognitive behavioral intervention integrating the four pillars of self-efficacy, Mastery, Social Modeling, Coaching, and Physiological Responses (West et al. 2008). Each week will comprise of a 1.5 hour session which focuses on an educational component, discussions and active learning practice activities to apply lesson material. Additionally, participants will be given take home exercises to practice outside a classroom setting. The sessions will be conducted in small groups of 4-6 people.

Memory Self-Efficacy Training

General Education BEHAVIORAL

The active control intervention will be a general education class consisting of real world knowledge and factual information on various topics unrelated to memory. This intervention will follow the same format as the memory self-efficacy training arm. One 1.5 hours session every week for 6 weeks, in small groups.

General Education Group

Eligibility Criteria

• Age: 60 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Subjective memory complaints within past 5 years
• Objective memory impairment below age norms on standardized cognitive testing
• Score below 25 on Montreal Cognitive Assessment
• Scores 1.5 standard deviations below age norms on memory testing
• Unimpaired performance in Activities of Daily Living
• Intact general cognition
• Fluently read, write and speak English
• Right handed

You may not qualify if:

• Co-morbidity that would impact cognition (depression, anxiety, stroke)
• Prior diagnosis of dementia of any type
• Use of prescription or recreational drug use that would impact cognition (excluding hormone replacement therapy)
• Uncorrected visual or auditory deficits/impairments
• Current participation in alternate study

Sponsors & Collaborators

• Western University, Canada: lead
• Western BrainsCAN: collaborator

Study Sites (1)

Community

London, Ontario, Canada

Location

MeSH Terms

Conditions

Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Masking Details: Participants will be unaware of the content of alternate groups. Both arms will be described as "Learning and Aging" groups to the participants
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: August 28, 2019
• First Posted: September 4, 2019
• Study Start: August 1, 2023
• Primary Completion: September 23, 2024
• Study Completion: September 23, 2024
• Last Updated: October 15, 2024

Record last verified: 2024-10

Locations

CA (1)