Memory Training and Neural Plasticity

NCT05380739 | Terminated

• 1 other identifier: HUM00199574
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

This study will evaluate the efficacy of working memory training in older adults with amnestic mild cognitive impairment (MCI).

Conditions

Mild Cognitive Impairment

Keywords

Working Memory; Training; fMRI

Outcome Measures

Primary Outcomes (2)

• Gains in WM training task performance

  Analyses of WM performance for each training session indexed as the mean set-size achieved during each training session for each participant

  2 weeks

• Changes in brain activation within the WM network

  Univariate analyses via fMRI and fNIRS, respectively, using units of brain activation (i.e., contrast estimates)

  2 weeks

Secondary Outcomes (2)

• Changes in criterion (fMRI) WM task performance

  2 weeks

• Changes in functional connectivity within and between canonical brain networks

  2 weeks

Study Arms (3)

In-Person, MCI

ACTIVE COMPARATOR

Participants diagnosed with MCI will undergo 10 sessions of WM training in person.

Behavioral: Working Memory Training

Online, MCI

ACTIVE COMPARATOR

Participants diagnosed with MCI will undergo 10 sessions of WM training online.

Behavioral: Working Memory Training

Online, Healthy

ACTIVE COMPARATOR

Cognitively intact older adults will undergo 10 sessions of WM training online.

Behavioral: Working Memory Training

Interventions

Working Memory Training BEHAVIORAL

A 10-session working memory (WM) training program

In-Person, MCI; Online, Healthy; Online, MCI

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• MCI Diagnosis
• Right-handedness
• MRI-eligibility for MRI participants

You may not qualify if:

• History of other contributing neurological or medical conditions known to affect cognitive functioning
• Significant mental illness
• Sensory impairments that limit ability to participate
• History of alcohol or drug abuse/dependence

Sponsors & Collaborators

• University of Michigan: lead

Study Sites (1)

University of Michigan

Ann Arbor, Michigan, 48109, United States

Location

MeSH Terms

Conditions

Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Officials

• Alexandru Iordan, Ph.D.

  University of Michigan

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Participants in the MCI group will be assigned to receive either in-person (Arm1) or online WM training (Arm2), based on their preference and availability of equipment ensuring a stable internet connection, for 10 training sessions. Participants in the HC group will receive online training (Arm3). Data for HC who received in-person training was already collected (HUM00033133). WM performance in conjunction with brain imaging will be assessed within-subject, twice pre-training (Time1 and Time2) and once post-training (Time3), as well as \~1 month after training (Follow-up). The Time1 vs. Time2 comparison will reveal task-exposure effects, whereas the Time2 vs. Time3 comparison will reveal training effects.

Study Record Dates

• First Submitted: April 27, 2022
• First Posted: May 19, 2022
• Study Start: April 7, 2022
• Primary Completion: May 11, 2023
• Study Completion: May 11, 2023
• Last Updated: October 20, 2025

Record last verified: 2025-10

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)