Causes of FUO in Infants and Children

NCT04073108 | Unknown

• 1 other identifier: cofouoiiacaauch
• Study Type: observational
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

Definition: fever \< 38˚c for which the cause could not be identified, documented by a health care provider after 3w.evaluation as an outpatient \[or after 1w. evaluation in the hospital\]. Most cases, however, do not have fever alone, but FUO results from atypical presentation of common diseases. On the other hand FUO lasting longer than 6mo is uncommon in children \& suggests granulomatous, autoimmune or auto inflammatory diseases

Conditions

Fever of Unknown Origin

Outcome Measures

Primary Outcomes (1)

• Causes of Fever of unknown origin (FUO) in infants and children attending Assiut University Children Hospital (AUCH)

  investigations

  Baseline

Interventions

tuberculin test DIAGNOSTIC_TEST

tuberclin test used to diagnose tuberculosis as cause of fever of unknown origin

Eligibility Criteria

• Age: 3 Months - 17 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

infants and children

You may qualify if:

• All FUO cases admitted to AUCH during one year of the study.

You may not qualify if:

• cases of HIV

Sponsors & Collaborators

• Assiut University: lead

Related Publications (4)

• Chien YL, Huang FL, Huang CM, Chen PY. Clinical approach to fever of unknown origin in children. J Microbiol Immunol Infect. 2017 Dec;50(6):893-898. doi: 10.1016/j.jmii.2015.08.007. Epub 2015 Oct 9.

  PMID: 27143687 BACKGROUND

• Attard L, Tadolini M, De Rose DU, Cattalini M. Overview of fever of unknown origin in adult and paediatric patients. Clin Exp Rheumatol. 2018 Jan-Feb;36 Suppl 110(1):10-24. Epub 2018 May 3.

  PMID: 29742054 BACKGROUND

• Antoon JW, Knudson-Johnson M, Lister WM. Diagnostic approach to fever of unknown origin. Clin Pediatr (Phila). 2012 Nov;51(11):1091-4. doi: 10.1177/0009922811431160. Epub 2011 Dec 12. No abstract available.

  PMID: 22166749 BACKGROUND

• Hassan RH, Fouda AE, Kandil SM. Fever of Unknown Origin in Children: A 6 year- Experience in a Tertiary Pediatric Egyptian Hospital. Int J Health Sci (Qassim). 2014 Jan;8(1):13-9. doi: 10.12816/0006067.

  PMID: 24899875 BACKGROUND

MeSH Terms

Conditions

Fever of Unknown Origin

Interventions

Tuberculin Test

Condition Hierarchy (Ancestors)

Fever; Body Temperature Changes; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Skin Tests; Immunologic Tests; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Investigative Techniques; Immunologic Techniques

Central Study Contacts

Safiea El-Deeb, prof

CONTACT

0220882060380; Safia.eldeeb@med.au.edu.eg

Mohammed Fathy, Ass.prof

CONTACT

02201005689353; mohamed.osman@med.au.edu.eg

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: August 3, 2019
• First Posted: August 29, 2019
• Study Start: October 1, 2019
• Primary Completion: October 1, 2020
• Study Completion: October 1, 2021
• Last Updated: August 29, 2019

Record last verified: 2019-08