Brief Summary

Retrospective cohort study of inpatients at a South Australian tertiary hospital who underwent 18F FDG-PET/CT for investigation of undifferentiated fever or inflammatory syndrome. The aim is to investigate the utility of FDG-PET/CT in the investigation of suspected infection in hospitalised adults. To establish the rate at which FDG-PET/CT contributes to a diagnosis, and how this impacts clinical management and outcomes. From this, to develop further understanding of for which patients this imaging modality contributes meaningfully to outcomes.

Trial Health

On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment

266

participants targeted

Target at P75+ for all trials

Timeline

Completed

Started Jan 2022

Typical duration for all trials

Geographic Reach

1 country

1 active site

Status

completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

2.1 years study duration

Study Start

First participant enrolled

January 4, 2022

Completed

2.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 29, 2024

Completed

Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 29, 2024

Completed

2.1 years until next milestone

First Submitted

Initial submission to the registry

February 18, 2026

Completed

6 days until next milestone

First Posted

Study publicly available on registry

February 24, 2026

Completed

Last Updated

February 24, 2026

Status Verified

February 1, 2026

Enrollment Period

2.1 years

First QC Date

February 18, 2026

Last Update Submit

February 18, 2026

Conditions

Fever of Unknown Origin Inflammation of Unknown Origin Fever Inflammation

Keywords

FDG-PET/CTPETfever of unknown origin

Outcome Measures

Primary Outcomes (1)

Diagnostic yield
• Did PET contribute to diagnostic yield?: * 1 = Yes: PET led to a finding either definitive e.g. confirmed by gold standard (microbiology, histopathology, intraoperative findings etc) or contributory, which guided diagnosis or management even without gold standard confirmation. Examples of contributory: PET showing vascular graft uptake, not explanted due to risk but presumptively treated Vertebral discitis suggested by PET, biopsied without culture, but presumptively treated and clinically improved PET negative - antibiotics ceased, patient remained well * 0 = No: PET provided no new information, was misleading (i.e. PET result contradicted by later results), or no action was taken based on PET
30 days