NCT04068051

Brief Summary

MOVEMENT (Multimechanistic Treatment over Time of Migraine Symptoms) is a Phase 3 study to evaluate the long-term safety of chronic intermittent use of AXS-07 and to assess the effect of AXS-07 on migraine symptoms following repeated treatment of migraine attacks.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
706

participants targeted

Target at P75+ for phase_3

Timeline
Completed

Started Jul 2019

Shorter than P25 for phase_3

Geographic Reach
1 country

51 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 6, 2019

Completed
21 days until next milestone

First Submitted

Initial submission to the registry

July 27, 2019

Completed
1 month until next milestone

First Posted

Study publicly available on registry

August 28, 2019

Completed
1.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 22, 2020

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 22, 2020

Completed
3 years until next milestone

Results Posted

Study results publicly available

October 10, 2023

Completed
Last Updated

October 10, 2023

Status Verified

September 1, 2023

Enrollment Period

1.2 years

First QC Date

July 27, 2019

Results QC Date

September 15, 2023

Last Update Submit

September 15, 2023

Conditions

Keywords

AxsomeAXS-07MoSEIC™ meloxicamrizatriptan

Outcome Measures

Primary Outcomes (1)

  • Long-term Safety of Chronic Intermittent Use of AXS-07

    Long-term safety as measured by: Subjects with any TEAEs Subjects with suspected to be drug-related TEAEs Subjects with serious TEAEs Subjects with TEAEs that led to drug withdrawal Subjects with TEAEs that led to withdrawal from study Subjects with TEAEs that resulted in death

    Up to 12 months

Study Arms (1)

AXS-07

EXPERIMENTAL
Drug: AXS-07

Interventions

AXS-07DRUG

AXS-07 (MoSEIC meloxicam and rizatriptan) taken by mouth for the acute treatment of migraine.

AXS-07

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Has participated in a prior study with AXS-07 for the treatment of migraine

You may not qualify if:

  • Has previously received any investigational drug or device or investigational therapy within 30 days before Screening, other than AXS-07
  • Pregnant, breastfeeding, or planning to become pregnant or breastfeed during the study

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (51)

Clinical Research Site

Birmingham, Alabama, 32516, United States

Location

Clinical Research Site

Birmingham, Alabama, 32542, United States

Location

Clinical Research Site

Mobile, Alabama, 36608, United States

Location

Clinical Research Site

Phoenix, Arizona, 85004, United States

Location

Clinical Research Site

Canoga Park, California, 91303, United States

Location

Clinical Research Site

Colton, California, 92324, United States

Location

Clinical Research Site

Encino, California, 91316, United States

Location

Clinical Research Site

Los Alamitos, California, 90720, United States

Location

Clinical Research Site

Los Angeles, California, 90017, United States

Location

Clinical Research Site

Los Angeles, California, 90048, United States

Location

Clinical Research Site

San Diego, California, 92103, United States

Location

Clinical Research Site

Spring Valley, California, 91978, United States

Location

Clinical Research Site

Walnut Creek, California, 94598, United States

Location

Clinical Research Site

Hallandale, Florida, 33009, United States

Location

Clinical Research Site

Jacksonville, Florida, 32256, United States

Location

Clinical Research Site

Lake City, Florida, 32055, United States

Location

Clinical Research Site

Lake Worth, Florida, 33467, United States

Location

Clinical Research Site

Miami, Florida, 33155, United States

Location

Clinical Research Site

Ocoee, Florida, 34761, United States

Location

Clinical Research Site

Orlando, Florida, 32801, United States

Location

Clinical Research Site

Ormond Beach, Florida, 32174, United States

Location

Clinical Research Site

Tampa, Florida, 33634, United States

Location

Clinical Research Site

Stockbridge, Georgia, 30281, United States

Location

Clinical Research Site

Evanston, Illinois, 60201, United States

Location

Clinical Research Site

Louisville, Kentucky, 40213, United States

Location

Clinical Research Site

Boston, Massachusetts, 02131, United States

Location

Clinical Research Site

North Dartmouth, Massachusetts, 02747, United States

Location

Clinical Research Site

Waltham, Massachusetts, 02451, United States

Location

Clinical Research Site

Ann Arbor, Michigan, 48104, United States

Location

Clinical Research Site

Minneapolis, Minnesota, 55402, United States

Location

Clinical Research Site

Springfield, Missouri, 65810, United States

Location

Clinical Research Site

Las Vegas, Nevada, 89102, United States

Location

Clinical Research Site

Albuquerque, New Mexico, 87102, United States

Location

Clinical Research Site

Manlius, New York, 13104, United States

Location

Clinical Research Site

Rochester, New York, 14609, United States

Location

Clinical Research Site

Williamsville, New York, 14221, United States

Location

Clinical Research Site

High Point, North Carolina, 27262, United States

Location

Clinical Research Site

Cincinnati, Ohio, 45212, United States

Location

Clinical Research Site

Columbus, Ohio, 43213, United States

Location

Clinical Research Site

Oklahoma City, Oklahoma, 73106, United States

Location

Clinical Research Site

Portland, Oregon, 97214, United States

Location

Clinical Research Site

Salem, Oregon, 97301, United States

Location

Clinical Research Site

Philadelphia, Pennsylvania, 19114, United States

Location

Clinical Research Site

Charleston, South Carolina, 29406, United States

Location

Clinical Research Site

Mt. Pleasant, South Carolina, 29464, United States

Location

Clinical Research Site

Knoxville, Tennessee, 37920, United States

Location

Clinical Research Site

Memphis, Tennessee, 38119, United States

Location

Clinical Research Site

Austin, Texas, 78731, United States

Location

Clinical Research Site

Salt Lake City, Utah, 84107, United States

Location

Clinical Research Site

Charlottesville, Virginia, 22911, United States

Location

Clinical Research Site

Seattle, Washington, 98105, United States

Location

MeSH Terms

Conditions

Migraine Disorders

Condition Hierarchy (Ancestors)

Headache Disorders, PrimaryHeadache DisordersBrain DiseasesCentral Nervous System DiseasesNervous System Diseases

Results Point of Contact

Title
Caroline Streicher, Vice President, Clinical Operations
Organization
Axsome Therapeutics, Inc.

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
Yes

Study Design

Study Type
interventional
Phase
phase 3
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 27, 2019

First Posted

August 28, 2019

Study Start

July 6, 2019

Primary Completion

September 22, 2020

Study Completion

September 22, 2020

Last Updated

October 10, 2023

Results First Posted

October 10, 2023

Record last verified: 2023-09

Data Sharing

IPD Sharing
Will not share

Locations