Effects of Age on Amino Acid Delivery to Tendon

NCT04064528 | Completed

• 1 other identifier: 1904022075
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Dietary amino acid supplementation may provide an effective means to promote tendon injury recovery and enhance collagen synthesis. While most published research has been completed in animal models, research with young adults has shown that a leucine-rich whey isolate consumed during a chronic resistance training (RT) intervention resulted in greater gains (\~60%) in tendon CSA when compared to placebo. Leucine-rich diets have also improved tendon collagen content in rodents. Further, in our preliminary work utilizing microdialysis, we demonstrate that oral consumption of a leucine-rich amino acid beverage increased delivery of amino acids to tendons in young adults (21-30 years). However, whether aging alters the delivery of amino acids to tendons after oral consumption has not be investigated. In order to optimize amino acid dosing for chronic interventional studies, we wish to determine if aging influences amino acid concentration in the peritendinous (space around the tendon) space after oral consumption.

Conditions

Aging

Keywords

amino acid; tendon; aging

Outcome Measures

Primary Outcomes (1)

• Achilles Peritendinous Amino Acid Levels in young and older adults

  Concentrations of amino acids will be measured from around the Achilles tendon

  0-6 hours post consumption

Study Arms (2)

Young

ACTIVE COMPARATOR

Young adults will be given a 10 g oral bolus of amino acids.

Dietary Supplement: Amino Acids

Older Adults

EXPERIMENTAL

Older adults will be given a 10 g oral bolus of amino acids.

Dietary Supplement: Amino Acids

Interventions

Amino Acids DIETARY_SUPPLEMENT

10 g bolus of essential amino acids

Older Adults; Young

Eligibility Criteria

• Age: 21 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may not qualify if:

• body mass index \>35 kg•m-2, those on medications known to affect protein or collagen metabolism, e.g. acetaminophen, ibuprofen, or prescription cyclooxygenase inhibitors, previous history of tendinopathy, or diabetes.

Sponsors & Collaborators

• Purdue University: lead

Study Sites (1)

Purdue University

West Lafayette, Indiana, 47907, United States

Location

MeSH Terms

Interventions

Amino Acids

Intervention Hierarchy (Ancestors)

Amino Acids, Peptides, and Proteins

Study Officials

• Chad C Carroll, PhD

  Purdue University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Model Details: Young (21-30 years old) and older (60-75 years) adults will each receive an oral bolus of 10 g of essential amino acids.

Study Record Dates

• First Submitted: August 20, 2019
• First Posted: August 22, 2019
• Study Start: September 6, 2019
• Primary Completion: August 1, 2022
• Study Completion: August 1, 2023
• Last Updated: December 14, 2023

Record last verified: 2023-12

Locations

US (1)