The Copmparison of Accuracy of PtcCO2 and in PetCO2 in COPD Patients
1 other identifier
observational
100
1 country
1
Brief Summary
The pathophysiological characteristics of COPD is irreversible airflow restriction which may influence the gas exchange and cause the abnormal PaO2 and PaCO2. Assessment of the partial arterial pressure of carbon dioxide (PaCO2 ) is the 'gold standard' for the evaluation of the adequacy of alveolar ventilation.Method used mostly nowadays : arterial puncture which is accurate but is invasive 、painful、 non-dynamic and there is risk of infection and tissue、nerve damage. Noninvasive measurement methods (Most commonly used)： end-tidal CO2（ ETCO2）、 transcutaneous CO2(TcCO2). They all can monitor the PaCO2 dynamically、 noninvasively, but is existence of controversy of the accuracy. So the investigators want to compare the accuracy of these two noninvasive methods for assessment of PaCO2.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Aug 2019
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 29, 2019
CompletedFirst Posted
Study publicly available on registry
August 9, 2019
CompletedStudy Start
First participant enrolled
August 10, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2020
CompletedOctober 23, 2019
October 1, 2019
10 months
July 29, 2019
October 21, 2019
Conditions
Outcome Measures
Primary Outcomes (2)
concordance between the values of PetCO2 and PaCO2 measured at the same time
concordance between the values of PetCO2 and PaCO2 measured at the same time
1 hour
concordance between the values of PtcO2 and PaCO2 measured at the same time
concordance between the values of PtcO2 and PaCO2 measured at the same time
1 hour
Study Arms (2)
stable COPD group
include COPD patients with stable state
AECOPD group
include COPD patients with acute exacerbation
Eligibility Criteria
stable and acute axcerbation COPD patients
You may qualify if:
- COPD patients
You may not qualify if:
- hemodynamics is unstable;
- any other lung disease despite COPD；
- other diseases influencing experiments: Cognitive impairment disease、 mouth and nose trauma.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, 510000, China
Related Publications (1)
Zha S, He Z, Niu J, Huang Q, Liang Z, Zhou Z, Yang H, Lin S, Guan L, Zhou L, Chen R. Comparison of prolonged exhalation end-tidal CO(2) and transcutaneous CO(2) monitoring in COPD patients. Crit Care. 2026 Jan 20. doi: 10.1186/s13054-025-05834-5. Online ahead of print.
PMID: 41559738DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- OTHER
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- doctor
Study Record Dates
First Submitted
July 29, 2019
First Posted
August 9, 2019
Study Start
August 10, 2019
Primary Completion
June 1, 2020
Study Completion
June 1, 2020
Last Updated
October 23, 2019
Record last verified: 2019-10