The Changes in End Expiratory Lung Impedence Measured by EIT and End Expiratory Lung Volume Measured by Passive Expiratory in Controlled Mechanical Ventilated Exacerbation COPD Patients

NCT05585060 | Unknown

• 1 other identifier: FAHGuangzhou_20220711
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

The pathophysiological characteristics of respiratory failure on exacerbation of chronic pulmonary obstructive disease are the rapid deteriorate of respiratory symptoms, combined with aggravated flow limitation, gas trapping, dynamic pulmonary hyperinflation (DPH), therefore the intrinsic PEEP (PEEPi) increases. It is worthwhile to explore bedside methods to quantify the changes in dynamic pulmonary hyperinflation to guide safe and effective mechanical ventilation in airflow limited patients.

Conditions

COPD

Keywords

COPD; dynamic pulmonary hyperinflation; mechanical ventilation; end expiratory lung impedence

Outcome Measures

Primary Outcomes (1)

• the changes of end expiratory lung volume

  measured by EIT and IC maneuver

  10 minutes

Secondary Outcomes (1)

• intrinsic PEEP

  10 minutes

Study Arms (1)

PEEP titration for mechanical ventilated AECOPD patients

EXPERIMENTAL

Pre- and post-self-controlled trials for invasive mechanical ventilated AECOPD patients during PEEP titration.

Diagnostic Test: the changes of end expiratory lung impedence; Diagnostic Test: the changes of end expiratory lung volume

Interventions

the changes of end expiratory lung impedence DIAGNOSTIC_TEST

the changes of end expiratory lung impedence measured by EIT

Also known as: △EELI

PEEP titration for mechanical ventilated AECOPD patients

the changes of end expiratory lung volume DIAGNOSTIC_TEST

the changes of end expiratory lung volume measured by apnea method

Also known as: △EELV

PEEP titration for mechanical ventilated AECOPD patients

Eligibility Criteria

• Age: 35 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• exacerbation COPD invasive ventilated patients admitted to the first affiliated Guangzhou medical university; 35 to 80 years old; in stable condition judged by clinicians

You may not qualify if:

• SpO2\<88%; instable hemodynamic (MAP\<65mmHg；Norepinephrine\> 0.1ug/kg.min); pregnancy; 4 hour intravenous diuretics use before research; chest deformity and trauma, subpleural pulmonary bulla; implanted electronic devices(cardiac pacemaker, implantable cardioversion defibrillator,ect); tumour or other organ dysfunction; refuse to signature the informed consent

Sponsors & Collaborators

• The First Affiliated Hospital of Guangzhou Medical University: lead

Study Sites (1)

The First Affiliated Hospital of Guangzhou Medical

Guangzhou, Guangdong, 510120, China

RECRUITING

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Rongchang Chen, PhD

  The First Affiliated Hospital of Guangzhou Medical University

  STUDY CHAIR

Central Study Contacts

Wei Fu, MD

CONTACT

+8602083062882; hooray_009@163.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: October 15, 2022
• First Posted: October 18, 2022
• Study Start: September 13, 2022
• Primary Completion: October 8, 2023
• Study Completion: October 8, 2023
• Last Updated: November 22, 2022

Record last verified: 2022-11

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)