The Effect of HFNC on Exercise Capacity Compared to VM in COPD Patients Recovering From Acute Evacerbation
The Effect of High Flow Nasal Cannula on Exercise Capacity Compared to Venturi Mask in COPD Patients Recovering From Acute Evacerbation
1 other identifier
interventional
10
1 country
1
Brief Summary
Early PR is thought to be effective in COPD patients recovering from acute exacerbation, while the effect of HFNC during exercise training in these patients remains unclear. The study may provide evidence of early PR in COPD patients recovering from acute exacerbation.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Aug 2021
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 11, 2021
CompletedFirst Submitted
Initial submission to the registry
October 16, 2021
CompletedFirst Posted
Study publicly available on registry
October 28, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 31, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
August 31, 2022
CompletedOctober 28, 2021
October 1, 2021
10 months
October 16, 2021
October 16, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Endurance time
Endurance time for 10 minute steping test
10 minute
Secondary Outcomes (3)
Respiratory pattern
10 minute
Work of breathing
10 minute
Neural respiratory drive
10 minute
Study Arms (2)
HFNC group
EXPERIMENTAL* Set FiO2 28% * Titrate the flow of HFNC at the highest tolerated value up to 60 L/min
VM group
ACTIVE COMPARATOR\- Keep FiO2 constant with VM and HFNC during the two trial
Interventions
HFNC provides humidified, heated, oxygen-enriched air at constant concentration with a flow up to 60L/min through a nasal cannula. It washouts the anatomical dead space and decreases the work of breathing.
Eligibility Criteria
You may qualify if:
- hospitalized AECOPD patients
- be ambulatory by 48h after admission for AECOPD
- requires oxygen by screening exercise test
You may not qualify if:
- active coronary ischemia
- respiratory diseases other than COPD
- unstable vital signs
- unstable psychological status
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Shiying
Guangzhou, Guangdong, 510120, China
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Rongchang Chen, PhD
The First Affiliated Hospital of Guangzhou Medical University
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
October 16, 2021
First Posted
October 28, 2021
Study Start
August 11, 2021
Primary Completion
May 31, 2022
Study Completion
August 31, 2022
Last Updated
October 28, 2021
Record last verified: 2021-10
Data Sharing
- IPD Sharing
- Will not share