Diaphragm Ultrasound in Neuromuscular Disorders
1 other identifier
observational
1,000
1 country
1
Brief Summary
Muscular dystrophies are neurologic disease with higher morbidity and mortality. Cardiac function and respiratory muscles can be affected, in addition with skeletal muscle deficiency . Lung function is classically assessed with functionnal pulmonary tests (FPT) . Ultrasound recently emerged as a non-invasive tool to assess diaphragm function. The aims of the study are:
- to provide the spectrum of diaphragm ultrasound in patients with muscular dystrophies
- to assess the correlation between diaphragm ultrasound and FPT
- to assess the correlation between diaphragm ultrasound and cardiac function
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started May 2019
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 15, 2019
CompletedFirst Submitted
Initial submission to the registry
July 22, 2019
CompletedFirst Posted
Study publicly available on registry
August 5, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 28, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
May 10, 2020
CompletedAugust 5, 2019
August 1, 2019
8 months
July 22, 2019
August 2, 2019
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
diaphragm ultrasound motion
using echography
1 year
Secondary Outcomes (4)
correlation between diaphragm motion (mm) and forced vital capacity(ml)
1 year
correlation between diaphragm motion (mm) and inspiratory capacity (ml)
1 year
diaphragm thickness (mm)
1 year
correlation between diaphargm thickness and maximal inspiratory pressure (cmH20)
1 year
Eligibility Criteria
Patients with neuromuscular diseases admitted for a cardio-respiratory function evaluation
You may qualify if:
- Duchenne muscular dystrophy,
- Becker muscular dystrophy,
- LGMD,
- myotonic dystrophy type 1 and type 2,
- metabolic myopathy,
- mitochondrial myopathy,
- FSHD1 and 2,
- myasthenia
You may not qualify if:
- history of cardiac surgery
- history of thoracic surgery
- brain traumatism
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Hopital Raymond Poincare
Garches, 92380, France
Related Publications (1)
Fayssoil A, Nguyen LS, Stojkovic T, Prigent H, Carlier R, Amthor H, Bergounioux J, Zini J, Damez-Fontaine S, Wahbi K, Laforet P, Nicolas G, Behin A, Bassez G, Leturcq F, Ben Yaou R, Mansencal N, Annane D, Lofaso F, Orlikowski D. Determinants of diaphragm inspiratory motion, diaphragm thickening, and its performance for predicting respiratory restrictive pattern in Duchenne muscular dystrophy. Muscle Nerve. 2022 Jan;65(1):89-95. doi: 10.1002/mus.27432. Epub 2021 Oct 25.
PMID: 34618930DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- MD PhD
Study Record Dates
First Submitted
July 22, 2019
First Posted
August 5, 2019
Study Start
May 15, 2019
Primary Completion
December 28, 2019
Study Completion
May 10, 2020
Last Updated
August 5, 2019
Record last verified: 2019-08