Relationship Between NLR and Prealbumin Levels With Diaphragm Thickness

NCT04014439 | Completed

• 1 other identifier: IndonesiaUAnes037
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

A study to find the relationship between neutrophil to lymphocyte ratio (NLR) with diaphragm thickness of critical patients in ICU.

Conditions

Inflammatory Response

Keywords

diaphragm thickness; neutrophil to lymphocyte ratio; mechanical ventilation

Outcome Measures

Primary Outcomes (2)

• Level of Prealbumin Serum

  5 days

• Ratio of Neutrophil to Lymphocyte

  5 days

Study Arms (2)

Normal Diaphragm

Diaphragm thickness is 2 mm or more

Diagnostic Test: Ratio of Neutrophil to Lymphocyte; Diagnostic Test: Level of Prealbumin Serum

Thinning Diaphragm

Diaphragm thickness is less than 2 mm

Diagnostic Test: Ratio of Neutrophil to Lymphocyte; Diagnostic Test: Level of Prealbumin Serum

Interventions

Ratio of Neutrophil to Lymphocyte DIAGNOSTIC_TEST

Each patient was examined for a blood sample of 6 ml of venous blood taken from the cubital vein using a vacuum tube without anticoagulants. Blood samples were centrifuged at a speed of 3500 rpm for 20 minutes. Samples are processed with abbott® devices, to obtain neutrophil and serum lymphocyte levels. Plasma samples are stored in the refrigerator -20 C. The patient's diaphragm thickness was measured on days 0, 3, 5 and then the measurement was compared. Diaphragm thickness was measured in patients using mechanical ventilation in intensive care rooms.

Normal Diaphragm; Thinning Diaphragm

Level of Prealbumin Serum DIAGNOSTIC_TEST

Each patient was examined for a blood sample of 6 ml of venous blood taken from the cubital vein using a vacuum tube without anticoagulants. Blood samples were centrifuged at a speed of 3500 rpm for 20 minutes. Samples are processed with abbott® devices, to obtain neutrophil and serum lymphocyte levels. Plasma samples are stored in the refrigerator -20 C. The patient's diaphragm thickness was measured on days 0, 3, 5 and then the measurement was compared. Diaphragm thickness was measured in patients using mechanical ventilation in intensive care rooms.

Normal Diaphragm; Thinning Diaphragm

Eligibility Criteria

• Age: 17 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients who are treated in intensive care unit and using mechanical ventilation from Day 0 till Day 5. These patients will be checked for their diaphragm thickness, level of prealbumin serums, and ratio of neutrophil to lymphocyte.

You may qualify if:

• Critical patients treated in intensive care unit using mechanical ventilation from day 0.
• Patients are clinically predicted to be treated for more than 5 days (qSOFA and clinical assessment)

You may not qualify if:

• History of suffering from neuromuscular disease and or diaphragmatic malformations
• Used non-invasive ventilation before starting to use mechanical ventilation
• History of tracheostomy
• Patients admitted to ICU within 12 months before this study

Sponsors & Collaborators

• Indonesia University: lead

Study Sites (1)

Indonesia University

Jakarta Pusat, DKI Jakarta, 10430, Indonesia

Location

Related Publications (5)

• Li C, Li X, Han H, Cui H, Wang G, Wang Z. Diaphragmatic ultrasonography for predicting ventilator weaning: A meta-analysis. Medicine (Baltimore). 2018 Jun;97(22):e10968. doi: 10.1097/MD.0000000000010968.

  PMID: 29851847 RESULT

• Flevari A, Lignos M, Konstantonis D, Armaganidis A. Diaphragmatic ultrasonography as an adjunct predictor tool of weaning success in patients with difficult and prolonged weaning. Minerva Anestesiol. 2016 Nov;82(11):1149-1157. Epub 2016 Jul 12.

  PMID: 27407022 RESULT

• Conti G, Montini L, Pennisi MA, Cavaliere F, Arcangeli A, Bocci MG, Proietti R, Antonelli M. A prospective, blinded evaluation of indexes proposed to predict weaning from mechanical ventilation. Intensive Care Med. 2004 May;30(5):830-6. doi: 10.1007/s00134-004-2230-8. Epub 2004 Mar 20.

  PMID: 15127195 RESULT

• Sellares J, Ferrer M, Cano E, Loureiro H, Valencia M, Torres A. Predictors of prolonged weaning and survival during ventilator weaning in a respiratory ICU. Intensive Care Med. 2011 May;37(5):775-84. doi: 10.1007/s00134-011-2179-3. Epub 2011 Mar 4.

  PMID: 21373820 RESULT

• Khan J, Harrison TB, Rich MM. Mechanisms of neuromuscular dysfunction in critical illness. Crit Care Clin. 2008 Jan;24(1):165-77, x. doi: 10.1016/j.ccc.2007.10.004.

  PMID: 18241784 RESULT

Study Officials

• Rudyanto Sedono

  Indonesia University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 7 Days
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medical Staff

Study Record Dates

• First Submitted: July 8, 2019
• First Posted: July 10, 2019
• Study Start: September 1, 2019
• Primary Completion: December 1, 2019
• Study Completion: December 1, 2019
• Last Updated: January 2, 2020

Record last verified: 2019-12

Locations

ID (1)