Effect of Aerobic or Resistance Exercise on the Endothelial Response in Post-acute Myocardial Infarction Patients Submitted to Angioplasty
1 other identifier
interventional
20
1 country
1
Brief Summary
Cardiac Rehabilitation, as art and acting science multiprofessional, is based on the training with exercises that provides the post-infarct patients to satisfactorily re-establish the patient's clinical condition and that improve the functional capacity of these individuals. Evidence shows that aerobic exercise training provides improvements in the endothelial function of this population. However, we do not yet have strong evidence of other modalities of exercise in these parameters in post-infarction patients treated with angioplasty.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Aug 2018
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 31, 2019
CompletedFirst Submitted
Initial submission to the registry
June 25, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
June 25, 2019
CompletedFirst Posted
Study publicly available on registry
June 27, 2019
CompletedJune 27, 2019
June 1, 2019
6 months
June 25, 2019
June 26, 2019
Conditions
Outcome Measures
Primary Outcomes (1)
Endothelial function
Flow-mediated dilatation technique
Pre and post 5 minutes exercise session
Secondary Outcomes (1)
Arterial stiffness
Pre and post 5 minutes exercise session
Study Arms (2)
Resistance exercise session
EXPERIMENTALAcute isometric session, about 20 minutes.
Aerobic exercise session
ACTIVE COMPARATORAcute aerobic session, about 20 minutes.
Interventions
Acute isometric exercise session performed with handgrip Jamar about 20 minutes monitored.
Eligibility Criteria
You may qualify if:
- Post-acute myocardial infarction patients
- Ergometric test 30 days after the infarction
- Ejection fraction\> 40% (Simpson's method)
- Regular use of optimized drugs
You may not qualify if:
- Unable to perform the randomized exercise
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Alexandre Lehnen
Porto Alegre, Rio Grande do Sul, 90620-001, Brazil
Related Publications (1)
Kollet DP, Marenco AB, Belle NL, Barbosa E, Boll L, Eibel B, Waclawovsky G, Lehnen AM. Aerobic exercise, but not isometric handgrip exercise, improves endothelial function and arterial stiffness in patients with myocardial infarction undergoing coronary intervention: a randomized pilot study. BMC Cardiovasc Disord. 2021 Feb 17;21(1):101. doi: 10.1186/s12872-021-01849-2.
PMID: 33596832DERIVED
Study Officials
- PRINCIPAL INVESTIGATOR
Alexandre Lehnen, PhD
Instituto de Cardiologia do Rio Grande do Sul
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- SUPPORTIVE CARE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 25, 2019
First Posted
June 27, 2019
Study Start
August 1, 2018
Primary Completion
January 31, 2019
Study Completion
June 25, 2019
Last Updated
June 27, 2019
Record last verified: 2019-06
Data Sharing
- IPD Sharing
- Will not share