Sevoflurane Effect on Left Atrial Performance: A Transoesophageal Echocardiographic Study
1 other identifier
observational
30
1 country
1
Brief Summary
The left atrial performance is affected by the preload as well as the afterload. The LA active pumping is increased by stretching of the LA but within limits, after which the active pumping declines. The LV stiffness acts as the LA afterload. Whenever the LV stiffness increases, the overall emptying fraction becomes more pumpdependent
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Jul 2019
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
June 23, 2019
CompletedFirst Posted
Study publicly available on registry
June 26, 2019
CompletedStudy Start
First participant enrolled
July 1, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 30, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2019
CompletedJanuary 3, 2020
December 1, 2019
3 months
June 23, 2019
December 31, 2019
Conditions
Outcome Measures
Primary Outcomes (1)
intraoperative transoesophageal echocardiography to test the effect of Sevoflurane on left atrial performance
Mitral inflow early diastolic velocity (meter/second)(m/s)
30 Minutes (Start point: After induction of anesthesia and before starting sevoflurane (first set of data). End point: After achieving one MAC sevoflurane anesthesia and before skin incision (second set of data)).
Eligibility Criteria
adult patients of any sex,40-75 years, maintaining sinus rhythm undergoing elective with preserved left ventricular systolic function.
You may qualify if:
- Clinical diagnosis of ischemic heart disease
- Elective coronary artery bypass grafting.
You may not qualify if:
- Atrial or ventricular dysrhythmias,
- Associated mitral valve disease,
- Ejection Fraction \<40%,
- Emergency coronary artery bypass grafting,
- Pericardial disease
- Contraindication to perform a TEE, e.g. Esophageal tumor
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Ain-Shams University Hospitals
Cairo, 11361, Egypt
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 3 Months
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor of Anesthesia and Intensive Care Department, Faculty of Medicine, Ain- shams University, Cairo, Egypt.
Study Record Dates
First Submitted
June 23, 2019
First Posted
June 26, 2019
Study Start
July 1, 2019
Primary Completion
September 30, 2019
Study Completion
December 31, 2019
Last Updated
January 3, 2020
Record last verified: 2019-12