Role Of Fixed Prosthodontic Restorations on Metabolic Control of Ischemic Heart Disease Patients

NCT07705672 | Completed

• 1 other identifier: Tanta-Dent-Cardio-2026-01
• Study Type: interventional
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

This study evaluated the effect of fixed prosthodontic rehabilitation on metabolic parameters and masticatory efficiency in patients with ischemic heart disease. Clinical and laboratory outcomes was assessed before and after treatment.

Conditions

Ischemic Heart Disease

Outcome Measures

Primary Outcomes (3)

• Change in Hemoglobin A1c (HbA1c)

  Hemoglobin A1c (HbA1c) (%) measured using standard laboratory methods. The mean change in HbA1c from baseline to 6 months after fixed prosthodontic rehabilitation will be assessed.

  Baseline and 6 months after fixed prosthodontic rehabilitation

• Change in High-Density Lipoprotein Cholesterol (HDL-C)

  High-density lipoprotein cholesterol (HDL-C) concentration (mg/dL) measured using standard laboratory blood analysis. The mean change in HDL-C from baseline to 6 months after fixed prosthodontic rehabilitation will be assessed.

  Baseline and 6 months after fixed prosthodontic rehabilitation

• Change in Low-Density Lipoprotein Cholesterol (LDL-C)

  Low-density lipoprotein cholesterol (LDL-C) concentration (mg/dL) measured using standard laboratory blood analysis. The mean change in LDL-C from baseline to 6 months after fixed prosthodontic rehabilitation will be assessed.

  Baseline and 6 months after fixed prosthodontic rehabilitation

Study Arms (1)

Fixed Prosthodontic Rehabilitation

EXPERIMENTAL

Placement of fixed prosthodontic restorations to replace missing teeth and improve masticatory function in patients with ischemic heart disease.

Procedure: Fixed Prosthodontic Rehabilitation

Interventions

Fixed Prosthodontic Rehabilitation PROCEDURE

Placement of fixed prosthodontic restorations to replace missing teeth and improve masticatory function.

Fixed Prosthodontic Rehabilitation

Eligibility Criteria

• Age: 45 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients aged 45 to 70 years with diagnosed stable ischemic heart disease.
• Patients presenting with partial edentulism and compromised masticatory function due to missing teeth.
• Patients indicated for fixed prosthodontic rehabilitation.
• Patients with complete clinical records and laboratory data available at baseline and 6 months after treatment.
• Patients who provided informed consent for treatment and use of their clinical data.

You may not qualify if:

• uncontrolled systemic diseases affecting metabolic status (e.g., uncontrolled diabetes mellitus).
• acute cardiovascular events or unstable ischemic heart disease.
• Patients with conditions affecting oral function other than tooth loss (e.g., neuromuscular disorders).
• Patients who received removable prostheses instead of fixed prosthodontic rehabilitation.
• Patients with incomplete clinical records or missing baseline or 6-month laboratory data.

Sponsors & Collaborators

• Dr. Moaz Mohamed: lead

Study Sites (1)

Faculty of Medicine

Tanta, Egypt

Location

MeSH Terms

Conditions

Myocardial Ischemia

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases; Vascular Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: lecturer of fixed prosthodontics

Study Record Dates

• First Submitted: July 6, 2026
• First Posted: July 15, 2026
• Study Start: January 1, 2024
• Primary Completion: September 12, 2025
• Study Completion: November 30, 2025
• Last Updated: July 15, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)