Brain Function and Decision-Making
2 other identifiers
interventional
36
1 country
1
Brief Summary
This study is about how brain function and structure is different between two universities. Participant in this project will contribute to a better understanding of how universities affect the brain.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Jun 2019
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 31, 2019
CompletedFirst Posted
Study publicly available on registry
June 4, 2019
CompletedStudy Start
First participant enrolled
June 20, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 16, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
March 16, 2020
CompletedResults Posted
Study results publicly available
February 6, 2023
CompletedFebruary 6, 2023
February 1, 2023
9 months
May 31, 2019
April 6, 2022
February 1, 2023
Conditions
Outcome Measures
Primary Outcomes (2)
Change in Prefrontal Cortex Brain Activity Assessed by fMRI
Blood-Oxygen-Level-Dependent signal change in the cognitive empathy brain network will be assessed using functional MRI
Baseline to 3 hours
Change in Accuracy of Empathic Pain Judgments
Difference in pain judgment scores rated from 1 (low) to 4 (high) between antisocial vs prosocial empathy trials
Baseline to 3 hours
Study Arms (2)
Low psychopathy distribution
OTHERParticipants who score at the low end of the psychopathy distribution
High psychopathy distribution
OTHERParticipants who score at the high end of the psychopathy distribution
Interventions
Participants will complete a psychological task that evokes antisocially- and prosocially-motivated empathic responding
Eligibility Criteria
You may qualify if:
- Undergraduate students aged 18 - 35 years of age
- No current or regular use of prescribed or illicit psychoactive drugs
- Free of major health problems (e.g., diabetes, HIV, Parkinson's disease)
- Free of a neurological or psychiatric disorders
- No current drug abuse (e.g., recreational drug use, average alcohol intake in excess of 4 drinks per day).
- Right hand dominant
- Free of claustrophobia
- Free of pregnancy or suspected pregnancy
- Absent MRI risk factors (e.g., implanted medical device, body mass index \> 35, braces)
- Free of medical conditions that render individuals with overly sensitive hearing
- No colorblindness
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Virginia Commonwealth University
Richmond, Virginia, 23298, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Results Point of Contact
- Title
- David Chester
- Organization
- Virginia Commonwealth University
Study Officials
- PRINCIPAL INVESTIGATOR
David Chester, PhD
Virginia Commonwealth University
Publication Agreements
- PI is Sponsor Employee
- Yes
- Restrictive Agreement
- No
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 31, 2019
First Posted
June 4, 2019
Study Start
June 20, 2019
Primary Completion
March 16, 2020
Study Completion
March 16, 2020
Last Updated
February 6, 2023
Results First Posted
February 6, 2023
Record last verified: 2023-02
Data Sharing
- IPD Sharing
- Will not share