NCT03964987|Completed
Pancreatic Duodenal Homeobox Factor-1 (PDX-1) and Neurogenin-3 (NGN-3) in Gestational Diabetes
PDX-1 and NGN-3 Expression in Gestational Diabetes
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PDX-1 and NGN-3 Expression in Gestational Diabetes
Sponsor study identifier
observational
48
1 country
1
Study Start
January 1, 2018
Actual (reported)Primary Completion
August 30, 2018
Actual (reported)Study Completion
December 31, 2018
Actual (reported)Introduction: Depletion of the ability of the cells ß to secrete the amount of insulin required by pregnancy, increasing the risk of develop Gestational Diabetes Mellitus (GDM). The aim was to contrast the messenger RNA (mRNA) expression of the pancreatic duodenal homeobox factor-1 (PDX-1) and Neurogenin-3 (Ngn-3) in peripheral blood of pregnant women with GDM versus women with normal pregnancies. Material and methods: This was a prospective, clinical and cross-sectional study, conforming two groups of pregnant women: a) patients with a healthy gestation and b) patients with GDM. Besides anthropometry and routine laboratorial test, real-time polymerase chain reaction (Real-Time PCR), was used to quantify the expression of PDX-1 and NGN-3.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 31, 2018
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 1, 2018
Actual (reported)August 30, 2018
Actual (reported)December 31, 2018
Actual (reported)May 21, 2019
Actual (reported)May 28, 2019
Actual (reported)ARNm expression
Expression of the genes PDX-1 and NGN-3
Nine months
Women with normoevolutionary gestation.
Patients with GDM.
Pregnant women attended in the Maternal-Fetal Medicine Service of the HMPMP.
Materno-Perinatal Hospital "Mónica Pretelini"
Toluca, 50130, Mexico
Sandikci M, Karagenc L, Yildiz M. Changes on the Pancreas in Experimental Diabetes and the Effect of Lycopene on These Changes: Pdx-1, Ngn-3, and Nestin Expressions. Anat Rec (Hoboken). 2017 Dec;300(12):2200-2207. doi: 10.1002/ar.23687. Epub 2017 Sep 26.
Gu G, Dubauskaite J, Melton DA. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development. 2002 May;129(10):2447-57. doi: 10.1242/dev.129.10.2447.
Hugo Mendieta Zerón, PhD.
Maternal-Perinatal Hospital "Mónica Pretelini Sáenz"
48 participants (actual enrollment reported by the registry).
First Submitted
May 21, 2019
First Posted
May 28, 2019
Study Start
January 1, 2018
Actual (reported)The Effect of Structured Training on the Decision to Have a GDM Screening Test.
Contact the study team to confirm eligibility.
Wang L, Fan H, Zhou L, Wu Y, Lu H, Luo J. Altered expression of PGC-1alpha and PDX1 and their methylation status are associated with fetal glucose metabolism in gestational diabetes mellitus. Biochem Biophys Res Commun. 2018 Jun 18;501(1):300-306. doi: 10.1016/j.bbrc.2018.05.010. Epub 2018 May 7.
Plows JF, Stanley JL, Baker PN, Reynolds CM, Vickers MH. The Pathophysiology of Gestational Diabetes Mellitus. Int J Mol Sci. 2018 Oct 26;19(11):3342. doi: 10.3390/ijms19113342.
Primary Completion
August 30, 2018
Actual (reported)Study Completion
December 31, 2018
Actual (reported)Last Updated
May 28, 2019
Record last verified: 2019-05
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Source: ClinicalTrials.gov.
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