NCT03964519

Brief Summary

This study evaluates different performance, physiological and neuromuscular changes after acute and chronic resistance training intervention in physically active men. The participants will train with a single exercise (full squat) and will be monitored with a linear encoder. The experiment will consist of between 3 to 6 sets between 70% to 85% of 1RM in the full squat exercise. Two main groups will form the intervention: one group will perform inter-set repetitions until there will be a 20% of velocity loss compared to the first repetition, while the second group will have a 40% of velocity loss.

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
30

participants targeted

Target at P25-P50 for not_applicable healthy

Timeline
Completed

Started Jul 2019

Shorter than P25 for not_applicable healthy

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

May 23, 2019

Completed
5 days until next milestone

First Posted

Study publicly available on registry

May 28, 2019

Completed
1 month until next milestone

Study Start

First participant enrolled

July 1, 2019

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 30, 2019

Completed
16 days until next milestone

Study Completion

Last participant's last visit for all outcomes

September 15, 2019

Completed
Last Updated

May 29, 2019

Status Verified

May 1, 2019

Enrollment Period

2 months

First QC Date

May 23, 2019

Last Update Submit

May 24, 2019

Conditions

Keywords

velocity lossTensiomiographyresistance training

Outcome Measures

Primary Outcomes (2)

  • Contraction time

    Time between 10% to 90% on the displacement-time curve assessed with the Tensiomiograhpy

    7 weeks

  • Maximum displacement

    Maximum displacement point the displacement-time curve assessed with the Tensiomiograhpy

    7 weeks

Secondary Outcomes (6)

  • Kinetic variables in the jump

    7 weeks

  • Muscle tissue oxygen

    7 weeks

  • Muscle temperature

    7 weeks

  • Mean propulsive velocity

    7 weeks

  • Amplitude (RMS) and frequency outputs

    7 weeks

  • +1 more secondary outcomes

Study Arms (3)

20% velocity loss

EXPERIMENTAL

This group will train with a variable number of repetitions during each set. The group will stop the set once the mean propulsive velocity will be 20% less compared to the first repetition.

Other: Acute changesOther: Chronic changesOther: Familiarization

40% velocity loss

EXPERIMENTAL

This group will train with a variable number of repetitions during each set. The group will stop the set once the mean propulsive velocity will be 40% less compared to the first repetition.

Other: Acute changesOther: Chronic changesOther: Familiarization

Control group

PLACEBO COMPARATOR

This group will be just tested as a control group.

Other: Chronic changesOther: Familiarization

Interventions

In a crossover design, participants will be randomized to perform on Day 1, 3 sets of repetitions (depending on each treatment group) at 70% or 1RM in the full squat exercise. 48-h later, same will be performed but in the contrary crossover arm.

20% velocity loss40% velocity loss

In a randomized control trial, participants will train during 6 weeks the full squat exercise, 2 days in the week (minimum between-days rest of 48h). Intensity will vary from 70% to 85 of 1RM, and training volume from 3 to 6 sets.

20% velocity loss40% velocity lossControl group

Prior to any intervention, all participants will perform a familiarization of the exercise session, together with a progressive resistance test to estimate the 1 RM

20% velocity loss40% velocity lossControl group

Eligibility Criteria

Age18 Years - 30 Years
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • To be healthy
  • Without injuries or actual illnesses
  • More than 2 years of experience in resistance training or federative sports

You may not qualify if:

  • To be sick or injured
  • To have programmed during the intervention phase a dramatic change in the lifestyle

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (15)

  • Pareja-Blanco F, Rodriguez-Rosell D, Sanchez-Medina L, Ribas-Serna J, Lopez-Lopez C, Mora-Custodio R, Yanez-Garcia JM, Gonzalez-Badillo JJ. Acute and delayed response to resistance exercise leading or not leading to muscle failure. Clin Physiol Funct Imaging. 2017 Nov;37(6):630-639. doi: 10.1111/cpf.12348. Epub 2016 Mar 11.

    PMID: 26970332BACKGROUND
  • Pareja-Blanco F, Rodriguez-Rosell D, Sanchez-Medina L, Sanchis-Moysi J, Dorado C, Mora-Custodio R, Yanez-Garcia JM, Morales-Alamo D, Perez-Suarez I, Calbet JAL, Gonzalez-Badillo JJ. Effects of velocity loss during resistance training on athletic performance, strength gains and muscle adaptations. Scand J Med Sci Sports. 2017 Jul;27(7):724-735. doi: 10.1111/sms.12678. Epub 2016 Mar 31.

    PMID: 27038416BACKGROUND
  • Moran-Navarro R, Martinez-Cava A, Sanchez-Medina L, Mora-Rodriguez R, Gonzalez-Badillo JJ, Pallares JG. Movement Velocity as a Measure of Level of Effort During Resistance Exercise. J Strength Cond Res. 2019 Jun;33(6):1496-1504. doi: 10.1519/JSC.0000000000002017.

    PMID: 29944141BACKGROUND
  • Sanchez-Medina L, Pallares JG, Perez CE, Moran-Navarro R, Gonzalez-Badillo JJ. Estimation of Relative Load From Bar Velocity in the Full Back Squat Exercise. Sports Med Int Open. 2017 Mar 28;1(2):E80-E88. doi: 10.1055/s-0043-102933. eCollection 2017 Feb. German.

    PMID: 30539090BACKGROUND
  • Gonzalez-Badillo JJ, Yanez-Garcia JM, Mora-Custodio R, Rodriguez-Rosell D. Velocity Loss as a Variable for Monitoring Resistance Exercise. Int J Sports Med. 2017 Mar;38(3):217-225. doi: 10.1055/s-0042-120324. Epub 2017 Feb 13.

    PMID: 28192832BACKGROUND
  • Rodriguez-Rosell D, Yanez-Garcia JM, Torres-Torrelo J, Mora-Custodio R, Marques MC, Gonzalez-Badillo JJ. Effort Index as a Novel Variable for Monitoring the Level of Effort During Resistance Exercises. J Strength Cond Res. 2018 Aug;32(8):2139-2153. doi: 10.1519/JSC.0000000000002629.

    PMID: 29781942BACKGROUND
  • Franz A, Behringer M, Harmsen JF, Mayer C, Krauspe R, Zilkens C, Schumann M. Ischemic Preconditioning Blunts Muscle Damage Responses Induced by Eccentric Exercise. Med Sci Sports Exerc. 2018 Jan;50(1):109-115. doi: 10.1249/MSS.0000000000001406.

    PMID: 28832392BACKGROUND
  • Rusu LD, Cosma GG, Cernaianu SM, Marin MN, Rusu PF, Ciocanescu DP, Neferu FN. Tensiomyography method used for neuromuscular assessment of muscle training. J Neuroeng Rehabil. 2013 Jul 3;10:67. doi: 10.1186/1743-0003-10-67.

    PMID: 23822158BACKGROUND
  • Gutierrez-Vargas R, Martin-Rodriguez S, Sanchez-Urena B, Rodriguez-Montero A, Salas-Cabrera J, Gutierrez-Vargas JC, Simunic B, Rojas-Valverde D. Biochemical and Muscle Mechanical Postmarathon Changes in Hot and Humid Conditions. J Strength Cond Res. 2020 Mar;34(3):847-856. doi: 10.1519/JSC.0000000000002746.

    PMID: 30024483BACKGROUND
  • Wiewelhove T, Raeder C, de Paula Simola RA, Schneider C, Doweling A, Ferrauti A. Tensiomyographic Markers Are Not Sensitive for Monitoring Muscle Fatigue in Elite Youth Athletes: A Pilot Study. Front Physiol. 2017 Jun 16;8:406. doi: 10.3389/fphys.2017.00406. eCollection 2017.

    PMID: 28670284BACKGROUND
  • Piqueras-Sanchiz F, Martin-Rodriguez S, Martinez-Aranda LM, Lopes TR, Raya-Gonzalez J, Garcia-Garcia O, Nakamura FY. Effects of moderate vs. high iso-inertial loads on power, velocity, work and hamstring contractile function after flywheel resistance exercise. PLoS One. 2019 Feb 7;14(2):e0211700. doi: 10.1371/journal.pone.0211700. eCollection 2019.

    PMID: 30730959BACKGROUND
  • de Paula Simola RA, Harms N, Raeder C, Kellmann M, Meyer T, Pfeiffer M, Ferrauti A. Assessment of neuromuscular function after different strength training protocols using tensiomyography. J Strength Cond Res. 2015 May;29(5):1339-48. doi: 10.1519/JSC.0000000000000768.

    PMID: 25474337BACKGROUND
  • Macgregor LJ, Hunter AM, Orizio C, Fairweather MM, Ditroilo M. Assessment of Skeletal Muscle Contractile Properties by Radial Displacement: The Case for Tensiomyography. Sports Med. 2018 Jul;48(7):1607-1620. doi: 10.1007/s40279-018-0912-6.

    PMID: 29605838BACKGROUND
  • Raeder C, Wiewelhove T, Simola RA, Kellmann M, Meyer T, Pfeiffer M, Ferrauti A. Assessment of Fatigue and Recovery in Male and Female Athletes After 6 Days of Intensified Strength Training. J Strength Cond Res. 2016 Dec;30(12):3412-3427. doi: 10.1519/JSC.0000000000001427.

    PMID: 27093538BACKGROUND
  • Giovanelli N, Taboga P, Rejc E, Simunic B, Antonutto G, Lazzer S. Effects of an Uphill Marathon on Running Mechanics and Lower-Limb Muscle Fatigue. Int J Sports Physiol Perform. 2016 May;11(4):522-9. doi: 10.1123/ijspp.2014-0602. Epub 2015 Sep 21.

    PMID: 26390075BACKGROUND

Study Officials

  • Alejandro Muñoz López, PhD

    Internship

    STUDY DIRECTOR
  • Jesus Gustavo Ponce, PhD

    Professor

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Jesus Gustazo Ponce, PhD

CONTACT

Alejandro Muñoz López, PhD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
OTHER
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Associate Professor

Study Record Dates

First Submitted

May 23, 2019

First Posted

May 28, 2019

Study Start

July 1, 2019

Primary Completion

August 30, 2019

Study Completion

September 15, 2019

Last Updated

May 29, 2019

Record last verified: 2019-05

Data Sharing

IPD Sharing
Will not share