UVB: Skin to Gut Study

NCT03962673 | Completed

• 1 other identifier: H17-00303
• Study Type: interventional
• Target: 23
• Locations: 1 country
• Sites: 1

Brief Summary

This research will explore the potential effects of Narrow-Band Ultra Violet B (NB-UVB) radiation on the intestinal microbiota composition and confirm a regulatory skin-to-gut axis during baseline conditions. Changes in the intestinal microbiota composition caused by NB-UVB phototherapy could be beneficial for patients with chronic/auto-inflammatory diseases like inflammatory bowel disease (IBD) by removing dangerous bacteria, increasing beneficial bacteria, and ultimately modulating immune responses.

Conditions

Healthy

Keywords

Phototherapy; Microbiome; Vitamin D

Outcome Measures

Primary Outcomes (2)

• Serum vitamin D

  The effect of UVB light exposures on the serum vitamin D concentrations

  1 week

• Microbiome

  Changes in the fecal microbiome composition after the UVB light exposures

  Before and after the UVB exposures (1 week apart)

Study Arms (1)

UVB- exposure

EXPERIMENTAL

Each participant will receive a pre-determined dose of UVB light. Serum Vitamin D and microbiome samples of each participant will be compared before and after the UVB light exposures.

Radiation: NB-UVB light exposure

Interventions

NB-UVB light exposure RADIATION

Participants are exposed to three low dose Narrow Band UVB light.

UVB- exposure

Eligibility Criteria

• Age: 19 Years - 40 Years
• Gender Eligibility Details: Healthy Caucasian females
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy Caucasian females
• Fitzpatrick skin type I, II or III

You may not qualify if:

• Skin photosensitivity due to medication
• Been on vacation to a sunny destination three months before enrollment
• Visit tanning beds on a regular basis in the past

Sponsors & Collaborators

• University of British Columbia: lead

Study Sites (1)

BC Childrens Hospital

Vancouver, British Columbia, V6H 3N1, Canada

Location

Related Publications (1)

• Bosman ES, Albert AY, Lui H, Dutz JP, Vallance BA. Skin Exposure to Narrow Band Ultraviolet (UVB) Light Modulates the Human Intestinal Microbiome. Front Microbiol. 2019 Oct 24;10:2410. doi: 10.3389/fmicb.2019.02410. eCollection 2019.

  PMID: 31708890 DERIVED

Study Officials

• Bruce A. Vallance, PhD

  BC Childrens Hospital Research Institute

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principle Investigator

Model Details: All participants are receiving the same treatment of which the UVB dose is adjusted for the participants Fitzpatrick skin type.

Study Record Dates

• First Submitted: May 22, 2019
• First Posted: May 24, 2019
• Study Start: February 19, 2018
• Primary Completion: April 27, 2018
• Study Completion: February 26, 2019
• Last Updated: May 24, 2019

Record last verified: 2019-05

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)