Neural Mechanisms of Attention Lapses in Adult ADHD

NCT03948607 | Completed

• 1 other identifier: 7248
• Study Type: observational
• Target: 63
• Locations: 1 country
• Sites: 1

Brief Summary

ADHD is a common disorder, leading to a significant disability that often persists in adulthood. ADHD is characterized by attentional disturbances that are difficult to asses with standard neuropsychological tests. Attention tends to stall after a certain time of fatigue (i.e. an attention lapse). The aim of this study is to study the electroencephalographic (EEG) characteristics of these attention lapses in a sustained attention task, comparing ADHD patients with healthy subjects.

Conditions

Attention Deficit Disorder; Hyperactivity Disorder

Keywords

Electroencephalography; Neurocognition; Attention deficit; Attention lapses

Outcome Measures

Primary Outcomes (1)

• Spectral amplitude of the alpha band (8-14 Hz) to the quantitative EEG during the period up to 20 seconds before the successful trials vs. missed trials (lapse).

  In healthy subjects, EEG changes, including increased parieto-occipital activity in the alphas frequency band (8-14Hz), have been observed 20 seconds before lapse (O'Connell et al., 2009). The analysis of the evoked potentials associated with the stimuli presented just before the occurrence of the target stimulus, reveals that the amplitude of the P300 on the 5 trials preceding the target to be detected is significantly lower before an omission (lapse) than before a correct detection.

  During EEG realized after the inclusion

Secondary Outcomes (8)

• CNV difference between missed and successful trials

  During EEG realized after the inclusion

• CNV difference between missed and successful trials

  During EEG realized after the inclusion

• Association between EEG lapses markers, neuropsychological measures of attention, clinical scales and subjective mindwandering

  During EEG realized after the inclusion

• Association between EEG lapses markers, neuropsychological measures of attention, clinical scales and subjective mindwandering

  During EEG realized after the inclusion

• Association between EEG lapses markers, neuropsychological measures of attention, clinical scales and subjective mindwandering

  During EEG realized after the inclusion

Study Arms (2)

Adult ADHD

Adult ADHD patients without current comorbidity and treatment.

Other: Electroencephalography during sustained attention task.

Healthy controls

Healthy controls without ADH, paired in age and gender.

Other: Electroencephalography during sustained attention task.

Interventions

Electroencephalography during sustained attention task. OTHER

The Continuous Temporal Expectancy Task (CTET) (O'Connell et al., 2009) is a very demanding discrimination task with sustained attention. It consists of the presentation on a computer screen of a visual pattern resembling a checkerboard that changes orientation at regular intervals of time. In this task the subject must respond (pressing a response button) to the appearance of rare target stimuli that have a longer duration (1120 ms) than non-target stimuli (800 ms). SART (Sustained Attention to Response Task) (Robertson et al., 1997) is a task of inhibition (Go / No-Go task) to evaluate the capacities of sustained attention. It consists in the successive and random presentation on a computer screen of the numbers from 1 to 9. In this task the subject must respond, by pressing a response button, to the appearance of all the numbers (very non-target stimuli frequent), with the exception of the number "3".

Also known as: CTET (Continuous Temporal Expectancy Task), SART (Sustained Attention to Response Task)

Adult ADHD; Healthy controls

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Patients included in the ADHD group are patients assessed during a specialized consultation on adult ADHD This consultation corresponds to standard care, during which a clinical examination is performed, as well as an interview with the psychiatrist. If the diagnosis of ADHD is confirmed, comorbidities are systematically sought and the eligibility criteria for inclusion of the patient in the study are verified. Healthy control are recruited by advertising.

You may qualify if:

• Diagnosis of ADHD according to DSM-5 criteria by a psychiatrist with clinical experience with ADHD
• aged 18 to 60
• having signed an informed consent
• able to understand the objectives and the risks related to the research
• For Healthy controls
• Absence of psychiatric disorder or neurological disease
• Matched in sex, age (± 2 years) and level of study (± 2 years) to each ADHD patient

You may not qualify if:

• treatment by Methylphenidate or amphetamine in the 3 months preceding the study
• treatment by a psychotropic drug other than antidepressant SSRI: anti-depressant non-SSRI, antipsychotic, mood stabilizer, benzodiazepine or hypnotic daily intake
• neurological pathology or neurological sequelae
• history of head trauma with loss of consciousness of more than 15 minutes
• Subject under the protection of justice
• Subject under guardianship, curatorship
• Impossibility to give the subject enlightened information (subject in emergency situation, difficulties of comprehension of the subject (for example mental retardation, illiteracy, subject not including French ...)

Sponsors & Collaborators

• University Hospital, Strasbourg, France: lead

Study Sites (1)

Hôpital Civil - service de Psychiatrie 2

Strasbourg, 67091, France

Location

MeSH Terms

Conditions

Attention Deficit Disorder with Hyperactivity

Condition Hierarchy (Ancestors)

Attention Deficit and Disruptive Behavior Disorders; Neurodevelopmental Disorders; Mental Disorders

Study Officials

• Sébastien WEIBEL

  Hôpitaux Universitaires de Strasbourg

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 11, 2019
• First Posted: May 14, 2019
• Study Start: September 10, 2019
• Primary Completion: May 5, 2021
• Study Completion: May 5, 2021
• Last Updated: April 18, 2023

Record last verified: 2023-04

Locations

FR (1)