Hamburg City Health Study - a German Cohort Study

NCT03934957 | Recruiting DMC

• 1 other identifier: PV5131
• Study Type: observational
• Target: 45,000
• Locations: 1 country
• Sites: 1

Brief Summary

The Hamburg City Health Study (HCHS) is a large, prospective, long-term, population-based cohort study and a unique research platform and network to obtain substantial knowledge about several risk and prognostic factors in major chronic diseases.

Conditions

Coronary Heart Disease; Stroke; Dementia; Cancer; Health Care; Vascular Diseases; Periodontal Diseases; Ocular Diseases; Respiratory Disease; Obesity

Keywords

Epidemiology; prospective cohort study; Nutrition; prevention; psychiatric and psychosomatic disorders

Outcome Measures

Primary Outcomes (1)

• self-reported Information on changes in health in the participants

  coronary artery disease atrial fibrillation heart failure dementia stroke cancer such as prostate cancer and skin cancer chronic kidney diseases migraine musculoskeletal diseases such as osteoporosis and bone metastasis ocular diseases such as glaucoma, macular degeneration, fundus hypertonicus, retinal vessel disease and neoplasm oral health including periodontal disease, oropharyngeal cancer and human papillomavirus (HPV)-infection psychiatric and psychosomatic disorders such as mental disorder or late - last depression pulmonary diseases such as obstructive lung disease sexual disorder skin diseases such as psoriasis, chronic wounds and inflammation vascular diseases such as aortic aneurysm, thrombosis and peripheral arterial disease

  yearly up to 12 years

Eligibility Criteria

• Age: 45 Years - 74 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Population based cohort, participants are identified by a random sample from the official inhabitant data file divided into gender and six age strata.

You may qualify if:

• Age 45 to 74 years
• Personally signed informed consent

You may not qualify if:

• Insufficient knowledge of the German language, in order to understand study documents and computer assisted interview without translation
• Physical or psychological incapability to travel to the study center and to cooperate in the investigations

Sponsors & Collaborators

• Universitätsklinikum Hamburg-Eppendorf: lead
• Universitäres Herzzentrum Hamburg-Eppendorf: collaborator
• Martini-Klinik am UKE GmbH: collaborator

Study Sites (1)

Universitätsklinikum Hamburg-Eppendorf

Hamburg, 20246, Germany

RECRUITING

Related Publications (9)

• Jensen M, Vettorazzi E, Weber P, Petersen M, Schell M, Nagele FL, Link MA, Schlemm E, Rimmele DL, Becher PM, Cheng B, Blankenberg S, Kirchhof P, Zeller T, Twerenbold R, Thomalla G. Association of Cardiac Biomarkers With Structural Brain Changes and Cognitive Impairment: Results From the Hamburg City Health Study. Neurology. 2025 Aug 12;105(3):e213865. doi: 10.1212/WNL.0000000000213865. Epub 2025 Jul 3.

  PMID: 40609062 DERIVED

• Wenzel JP, Albrecht JN, Toprak B, Petersen E, Nikorowitsch J, Cavus E, Jahnke C, Riedl KA, Adam G, Twerenbold R, Blankenberg S, Kirchhof P, Lund G, Tahir E, Mullerleile K, Radunski UK. Head-to-head comparison of cardiac magnetic resonance imaging and transthoracic echocardiography in the general population (MATCH). Clin Res Cardiol. 2025 May 12. doi: 10.1007/s00392-025-02660-1. Online ahead of print.

  PMID: 40353872 DERIVED

• Rimmele DL, Petersen EL, Affolderbach S, Petersen M, Cheng B, Mayer C, Nagele FL, Harth V, Terschuren C, Kuhn S, Zeller T, Gerloff C, Thomalla G. Differences in impact of current and former shift work on cardiovascular risk factors, carotid atherosclerosis, and white matter integrity. Sleep Adv. 2024 Jul 31;5(1):zpae056. doi: 10.1093/sleepadvances/zpae056. eCollection 2024.

  PMID: 39156216 DERIVED

• Cavus E, Schneider JN, di Carluccio E, Ziegler A, Haack A, Ojeda F, Chevalier C, Jahnke C, Riedl KA, Radunski UK, Twerenbold R, Kirchhof P, Blankenberg S, Adam G, Tahir E, Lund GK, Muellerleile K. Unrecognized myocardial scar by late-gadolinium-enhancement cardiovascular magnetic resonance: Insights from the population-based Hamburg City Health Study. J Cardiovasc Magn Reson. 2024 Summer;26(1):101008. doi: 10.1016/j.jocmr.2024.101008. Epub 2024 Feb 9.

  PMID: 38341145 DERIVED

• Rimmele DL, Borof K, Wenzel JP, Jensen M, Behrendt CA, Waldeyer C, Schnabel RB, Zeller T, Debus ES, Blankenberg S, Gerloff C, Thomalla G. Differential association of flow velocities in the carotid artery with plaques, intima media thickness and cardiac function. Atheroscler Plus. 2021 Jul 31;43:18-23. doi: 10.1016/j.athplu.2021.07.020. eCollection 2021 Sep.

  PMID: 36644504 DERIVED

• Cavus E, Schneider JN, Bei der Kellen R, di Carluccio E, Ziegler A, Tahir E, Bohnen S, Avanesov M, Radunski UK, Chevalier C, Jahnke C, Ojeda F, Kirchhof P, Blankenberg S, Adam G, Lund GK, Muellerleile K. Impact of Sex and Cardiovascular Risk Factors on Myocardial T1, Extracellular Volume Fraction, and T2 at 3 Tesla: Results From the Population-Based, Hamburg City Health Study. Circ Cardiovasc Imaging. 2022 Sep;15(9):e014158. doi: 10.1161/CIRCIMAGING.122.014158. Epub 2022 Sep 20.

  PMID: 36126126 DERIVED

• Rimmele DL, Petersen EL, Schlemm E, Kessner SS, Petersen M, Mayer C, Cheng B, Zeller T, Waldeyer C, Behrendt CA, Gerloff C, Thomalla G. Association of Carotid Plaque and Flow Velocity With White Matter Integrity in a Middle-aged to Elderly Population. Neurology. 2022 Dec 12;99(24):e2699-e2707. doi: 10.1212/WNL.0000000000201297.

  PMID: 36123124 DERIVED

• Zyriax BC, Borof K, Walter S, Augustin M, Windler E. Knowledge as to cholesterol reduction and use of phytosterol-enriched dietary foods in the general population: Insights from the Hamburg City Health Study. Atherosclerosis. 2022 Jan;341:1-6. doi: 10.1016/j.atherosclerosis.2021.12.004. Epub 2021 Dec 12.

  PMID: 34922192 DERIVED

• Jacobi N, Walther C, Borof K, Heydecke G, Seedorf U, Lamprecht R, Beikler T, Debus SE, Waldeyer C, Blankenberg S, Schnabel RB, Aarabi G, Behrendt CA. The Association of Periodontitis and Peripheral Arterial Occlusive Disease in a Prospective Population-Based Cross-Sectional Cohort Study. J Clin Med. 2021 May 11;10(10):2048. doi: 10.3390/jcm10102048.

  PMID: 34064657 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

serum, plasma (EDTA, citrate), genomic deoxyribonucleic acid (DNA), ribonucleic acid (RNA) from whole blood and peripheral blood mononuclear cells (PBMCs), blood cells (erythrocytes, PBMCs), urine, saliva, tooth fluid, tonsils swabs

MeSH Terms

Conditions

Coronary Disease; Stroke; Dementia; Neoplasms; Vascular Diseases; Periodontal Diseases; Respiration Disorders; Obesity; Psychophysiologic Disorders

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurocognitive Disorders; Mental Disorders; Mouth Diseases; Stomatognathic Diseases; Respiratory Tract Diseases; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Neurologic Manifestations

Study Officials

• Stefan Blankenberg, Professor

  Universitäres Herzzentrum Hamburg

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Annika Jagodzinski, MD

CONTACT

0049741059328; A.Jagodzinski@uke.de

Tanja Zeller, Professor

CONTACT

0049741056045; t.zeller@uke.de

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 4, 2019
• First Posted: May 2, 2019
• Study Start: February 8, 2016
• Primary Completion: December 31, 2022
• Study Completion (Estimated): December 31, 2028
• Last Updated: May 2, 2019

Record last verified: 2019-04

Data Sharing

• IPD Sharing: Will not share

Locations

DE (1)