Erbium-YAG Laser Versus Platelet Rich Plasma in the Treatment of Atrophic Acne Scars
Fractional Erbium-YAG Laser Versus Platelet Rich Plasma in the Treatment of Atrophic Acne Scars: A Randomized Clinical Trial
1 other identifier
interventional
75
1 country
1
Brief Summary
This study aim to assess the efficacy of Er-YAG laser 2940nm and PRP as a single line of treatment in comparison with combined treatment in atrophic post acne scars.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Jun 2017
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 31, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
February 28, 2019
CompletedFirst Submitted
Initial submission to the registry
April 25, 2019
CompletedFirst Posted
Study publicly available on registry
May 1, 2019
CompletedMay 1, 2019
April 1, 2019
1.2 years
April 25, 2019
April 27, 2019
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
Change in grade of acne scares according toQualitative scarring grading system of Goodman and Baron
Grade of acne scares improvement after treatment
6 months
Change in clinical appearance of acne scare accordinga four-point scale for assessment of clinical improvement of skin smoothness
improvement of acne scares as evaluated by sequential photos
6 month
Change in patient satisfaction usinga four-point scale; Grade 4 highly satisfied, Grade 3 satisfied, Grade 2 neutral and Grade 1 dissatisfied
increase in patient satisfaction after treatment
6 month
Study Arms (3)
Group A
ACTIVE COMPARATORtreated with platelet rich plasma
Group B
ACTIVE COMPARATORtreated with Erbium Yag Laser
Group C
ACTIVE COMPARATORtreated with both line of treatments
Interventions
Eligibility Criteria
You may qualify if:
- patients with atrophic post acne scars classified on the basis of Goodman and Baron's Qualitative classification, no active acne lesions and patients with atrophic scars only
You may not qualify if:
- patients with positive history of keloidal tendency, positive history of bleeding tendency, platelet disorder, patients with any acute infection on face like, herpes, folliculitis, patients with HIV, HBsAg, patients with a history of autoimmune diseases or patients on immunosuppressive drugs.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Aswan University Hospitallead
- South Valley Universitycollaborator
Study Sites (1)
Aswan University Hospital
Aswān, 81528, Egypt
Related Publications (1)
El-Taieb MA, Ibrahim HM, Hegazy EM, Ibrahim AK, Gamal AM, Nada EA. Fractional Erbium-YAG Laser and Platelet-Rich Plasma as Single or Combined Treatment for Atrophic Acne Scars: A Randomized Clinical Trial. Dermatol Ther (Heidelb). 2019 Dec;9(4):707-717. doi: 10.1007/s13555-019-00318-1. Epub 2019 Aug 16.
PMID: 31420849DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Ass. Prof. of Dermatology, Venereology and Andrology
Study Record Dates
First Submitted
April 25, 2019
First Posted
May 1, 2019
Study Start
June 1, 2017
Primary Completion
August 31, 2018
Study Completion
February 28, 2019
Last Updated
May 1, 2019
Record last verified: 2019-04
Data Sharing
- IPD Sharing
- Will not share