NCT03926325

Brief Summary

BASIC is a perspective, multicentre and large-scale registry focusing on of patients suffering a cardiac arrest in China. The aims of the study are to establish the monitoring sites covering out-of-hospital cardiac arrest (OHCA) and in-hospital cardiac arrest (IHCA) in urban and rural areas in 7 regions (East China, North China, South China, Central China, Northeast China, Southwest China and Northwest China) around China, to collect data from cardiac arrest patients, and to describe basic characteristics, treatments, outcomes, incidences and risk factors of OHCA and IHCA in China.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
200,000

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jul 2019

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

April 19, 2019

Completed
5 days until next milestone

First Posted

Study publicly available on registry

April 24, 2019

Completed
2 months until next milestone

Study Start

First participant enrolled

July 1, 2019

Completed
4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 30, 2023

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2023

Completed
Last Updated

October 4, 2022

Status Verified

October 1, 2022

Enrollment Period

4 years

First QC Date

April 19, 2019

Last Update Submit

October 2, 2022

Conditions

Cardiac Arrest

Outcome Measures

Primary Outcomes (5)

  • incidence of OHCA treated by EMS

    Latest data inclusion June 30, 2022

  • incidence of IHCA

    Latest data inclusion June 30, 2022

  • survival to hospital discharge or 30d survival of OHCA

    at hospital discharge, 30days after cardiac arrest occurs

  • survival to hospital discharge or 30d survival of IHCA

    at hospital discharge, 30days after cardiac arrest occurs

  • prevalence of favorable neurological outcome after cardiac arrest according to Cerebral Performance Category (CPC) Scale

    CPC 1 and 2 as a favorable neurological outcome; CPC 1, Good Cerebral Performance; CPC 2, Moderate Cerebral Disability; CPC 3, Severe Cerebral Disability; CPC 4, Coma, vegetative state; CPC 5, Brain death

    at hospital discharge, 30days after cardiac arrest occurs

Secondary Outcomes (4)

  • survival of OHCA

    6 months and 1 year after cardiac arrest occurs

  • survival of IHCA

    6 months and 1 year after cardiac arrest occurs

  • prevalence of favorable neurological outcome after cardiac arrest according to Cerebral Performance Category (CPC) Scale

    6 months and 1 year after cardiac arrest occurs

  • rate of return of spontaneous circulation

    Latest data inclusion June 30,2022

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

consecutive patients with cardiac arrest

You may qualify if:

  • OHCA: Every patient who suffered a cardiac arrest that occurred in any location other than a hospital, and was attended and/or treated by an EMS.
  • IHCA: Every patient who suffered a cardiac arrest in hospital.
  • the representative population-based survey: Every patient who suffered a cardiac arrest in the selected cities or suburbs.

You may not qualify if:

  • OHCA: 1)The out-of-hospital cardiac arrest patients who were taken to the hospital by their family members; 2) Bystanders suspected cardiac arrest, but the ROSC was achieved without defibrillation or resuscitation by EMS.
  • IHCA: The patient who suffered a cardiac arrest that occurred out-of-hospital and then transferred to the hospital.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Qilu Hospital of Shandong University

Jinan, Shandong, 250012, China

RECRUITING

Related Publications (1)

  • Xie X, Zheng J, Zheng W, Pan C, Ma Y, Zhu Y, Tan H, Han X, Yan S, Zhang G, Li C, Shao F, Wang C, Zhang J, Bian Y, Ma J, Cheng K, Liu R, Sang S, Zhang Y, McNally B, Ong MEH, Lv C, Chen Y, Xu F; BASIC-OHCA Coordinators and Investigators. Efforts to Improve Survival Outcomes of Out-of-Hospital Cardiac Arrest in China: BASIC-OHCA. Circ Cardiovasc Qual Outcomes. 2023 Feb;16(2):e008856. doi: 10.1161/CIRCOUTCOMES.121.008856. Epub 2022 Dec 12.

    PMID: 36503279DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

blood samples of cardiac arrest patients in certain centers

MeSH Terms

Conditions

Heart Arrest

Condition Hierarchy (Ancestors)

Heart DiseasesCardiovascular Diseases

Study Officials

  • Feng Xu, Dr

    Qilu Hospital of Shandong University

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Feng Xu, Dr

CONTACT

+86-18560083066xufengsdu@126.com

Chang Pan, Dr

CONTACT

+86-18560082290panchang0517@163.com

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
3 Years
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Director of Emergency Department

Study Record Dates

First Submitted

April 19, 2019

First Posted

April 24, 2019

Study Start

July 1, 2019

Primary Completion

June 30, 2023

Study Completion

December 31, 2023

Last Updated

October 4, 2022

Record last verified: 2022-10

Locations

CN(1)