Circulating Biomarkers Predict Neurological Outcome After Cardiac Arrest

NCT02297776 | Unknown DMC

• 1 other identifier: 040114001
• Study Type: observational
• Target: 160
• Locations: 1 country
• Sites: 1

Brief Summary

Prediction of clinical outcome after cardiac arrest is clinically important.Early prognostication after successful cardiopulmonary resuscitation is difficult, and there is a need for novel methods to estimate the extent of brain injury and predict outcome. In this study, the investigators will evaluate the plasma levels of microRNAs (miRNAs) and circRNAs after cardiac arrest and assessed their ability to prognosticate neurological outcome.

Conditions

Cardiac Arrest

Keywords

cardiac arrest; biomarker; microRNA; circRNA; NSE; CPC

Outcome Measures

Primary Outcomes (1)

• cerebral performance Category（CPC) of Participants

  up to 6 months after cardiopulmonary resuscitation

Secondary Outcomes (2)

• survival of participants

  up to 28 days after hospitalization

• cerebral performance Category（CPC) of Participants

  up to 2 weeks after cardiopulmonary resuscitation

Study Arms (2)

CPC score 1 to 2

The patients with CPC score 1 to 2 judged half a year after cardiac arrest

CPC scores 3 to 5

The patients with CPC score 3 to 5 judged half a year after cardiac arrest

Eligibility Criteria

• Age: 14 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

transferred to or hospitalized in the emergency department or other wards of Shanghai Tenth People's Hospital due to cardiac arrest

You may qualify if:

• Transferred to or hospitalized in the emergency department or other wards of Shanghai Tenth People's Hospital due to cardiac arrest;
• Return of spontaneous circulation (ROSC)after cardiopulmonary resuscitation;
• Age \> 14 years and \< 85 years;
• Written informed consent was obtained from all patients'family members before entering the study.

You may not qualify if:

• No witnesses when cardiac arrest occurs;
• Obvious neurological dysfunction prior to cardiac arrest;
• Intracranial infection or cerebrovascular accidents as primary disease or secondary complication within six months in the follow-up period.

Sponsors & Collaborators

• Shanghai 10th People's Hospital: lead

Study Sites (1)

Shanghai Tenth Hospital

Shanghai, 200000, China

RECRUITING

Related Publications (1)

• Zhuang YG, Chen YZ, Zhou SQ, Peng H, Chen YQ, Li DJ. High plasma levels of pro-inflammatory factors interleukin-17 and interleukin-23 are associated with poor outcome of cardiac-arrest patients: a single center experience. BMC Cardiovasc Disord. 2020 Apr 15;20(1):170. doi: 10.1186/s12872-020-01451-y.

  PMID: 32293300 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

Plasma samples are to be retained.

MeSH Terms

Conditions

Heart Arrest

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Study Officials

• Yuanzhuo Chen, MD

  Shanghai 10th People's Hospital

  STUDY CHAIR

• Wenjie Li, MD

  Shanghai 10th People's Hospital

  PRINCIPAL INVESTIGATOR

• Huiqi Wang, MD

  Shanghai 10th People's Hospital

  PRINCIPAL INVESTIGATOR

• Chengjin Gao, MD

  Shanghai 10th People's Hospital

  STUDY DIRECTOR

• Hu Peng, MD

  Shanghai 10th People's Hospital

  STUDY DIRECTOR

• Yugang Zhuang, MD

  Shanghai 10th People's Hospital

  PRINCIPAL INVESTIGATOR

• Xiangyu Zhang, MD

  Shanghai 10th People's Hospital

  STUDY DIRECTOR

• Qixing Wang

  Shanghai 10th People's Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Yuanzhuo Chen, MD

CONTACT

+821666304586; chenyuanzhuo021@hotmail.com

Wenjie Li, MD

CONTACT

kingnever@hotmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: M.D.

Study Record Dates

• First Submitted: November 16, 2014
• First Posted: November 21, 2014
• Study Start: August 1, 2014
• Primary Completion: August 1, 2016
• Study Completion: August 1, 2016
• Last Updated: November 24, 2014

Record last verified: 2014-11

Locations

CN (1)