Hyperoxia Before and After Cardiac Arrest and Myocardial Damage

NCT03571074 | Completed

• 1 other identifier: HyperoxiaandCardiacarrest
• Study Type: observational
• Target: 163
• Locations: 1 country
• Sites: 1

Brief Summary

Several studies show how patients with hyperoxia after cardiac arrest has increased mortality, but the association of hyperoxia before cardiac arrest and myocardial damage has never been investigated. Neither has the association between hyperoxia after cardiac arrest and myocardial injury. Our research hypothesis is that hyperoxia before cardiac arrest aggravates myocardial damage, secondly we wish to analyze the association between hyperoxia after cardiac arrest and myocardial injury. The exposure variables is oxygenation within 48 hours before and 48 hours after cardiac arrest, our primary outcome is myocardial damage and will be measured as peak troponin within 30 days after cardiac arrest.

Conditions

Cardiac Arrest

Outcome Measures

Primary Outcomes (1)

• Peak troponin within 30 days after cardiac arrest

  Troponin measurements on patients after cardiac arrest.

  30 days

Secondary Outcomes (4)

• 30-day and 1-year mortality

  Up to 1 year.

• Troponin area under the curve within 3 days after cardiac arrest

  3 days

• Length of ICU stay after cardiac arrest

  through study completion,on average of 4-8 weeks.

• Length of hospital stay after cardiac arrest

  through study completion,on average of 4-8 weeks.

Study Arms (3)

Hypoxia

Defined as a group of patients with oxygen saturation \<94 % irrespective of supplemental oxygen. If COPD, defined as oxygen saturation \<88 % irrespective of supplemental oxygen.

Other: Oxygenation

Normoxia

Defined as a group of patients with oxygen saturation 94 % - 98 % in combination of supplemental oxygen, or oxygen saturation \>94 % without supplemental oxygen. If COPD, defined as oxygen saturation 88 % - 92 % in combination of supplemental oxygen, or oxygen saturation \>88 % without supplemental oxygen.

Other: Oxygenation

Hyperoxia

Defined as a group of patients with oxygen saturation \>98 % in combination of supplemental oxygen. If COPD, defined as oxygen saturation \>92 % in combination of supplemental oxygen.

Other: Oxygenation

Interventions

Oxygenation OTHER

Oxygenation measured as oxygen supply and saturation before cardiac arrest, and oxygenation measured as PaO2 after cardiac arrest.

Hyperoxia; Hypoxia; Normoxia

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with in hospital cardiac arrest, who had return of spontaneus circulaiton and was then admitted to ICU in a hospital in the Capital Region of Denmark.

You may qualify if:

• years or older
• With a record of ICD-10 diagnosis of cardiac arrest in 2014, admitted to a hospital in the Capital Region of Denmark.
• First recorded cardiac arrest in 2014
• Admitted to ICU
• Serum troponin measured within 7 days after cardiac arrest

You may not qualify if:

• Out of hospital cardiac arrest, OHCA
• In of hospital cardiac arrest, IHCA, but with no registered saturation before cardiac arrest.

Sponsors & Collaborators

• University Hospital Bispebjerg and Frederiksberg: lead

Study Sites (1)

Bispebjerg Hospital

Copenhagen, 2400, Denmark

Location

MeSH Terms

Conditions

Heart Arrest

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Assistant, Bispebjerg Hospital.

Study Record Dates

• First Submitted: June 4, 2018
• First Posted: June 27, 2018
• Study Start: May 30, 2018
• Primary Completion: August 10, 2018
• Study Completion: September 30, 2018
• Last Updated: October 23, 2018

Record last verified: 2018-10

Locations

DK (1)