Serum and Urine Ghrelin in Adult Epileptic Patients

NCT03926273 | Completed DMC

• 1 other identifier: ZU-IRB#5271\ 2-6-2018
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Several neuropeptides have concerned with epilepsy pathogenesis, ghrelin showed an anticonvulsant effect. There is a potential relation between its level and antiepileptic drugs (AED) response.

Conditions

Epilepsy

Keywords

epilepsy; serum ghrelin; urine ghrelin

Outcome Measures

Primary Outcomes (2)

• Serum ghrelin in Adult Epileptic Patients

  evaluation of the effect of Serum ghrelin in adult epileptic patients and in their response to anti- epileptic drugs

  6 months

• Urine ghrelin in Adult Epileptic Patients

  evaluation of the effect of Urine ghrelin in adult epileptic patients and in their response to anti- epileptic drugs

  6 months

Study Arms (2)

group 1

Epileptic participants group consisted of 40 adults (15 females and 25 males) clinically and electrophysiological were diagnosed according to the international league against epilepsy classification 2010.

group 2

Control group consisted of 40 adults (16 females and 24 males) non - epileptic healthy subjects.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The present study was a case control type. All patients were selected from out- patient clinic of Neurology department, Zagazig university hospitals, Sharkia Governorate, Egypt in the period from July 2018 to January 2019.

You may qualify if:

• All participants were included if their age more than or equal to 18 years. Body mass index \< 30 kg/m2, total cholesterol \< 200mg/dl, serum triglycerides \< 200 mg/dl and random blood glucose level \< 126 mg/dl.

You may not qualify if:

• Participants had acute or chronic metabolic disorders (liver, kidney, thyroid, endocrine or gastrointestinal disorders).
• Females with irregular menstrual cycle or on estrogen therapy (7).
• Participants with organic cerebral lesion that was detected on cranial computed tomography (CT) or cranial magnetic resonance imaging (MRI).

Sponsors & Collaborators

• Zagazig University: lead

Study Sites (1)

Nageeb

Zagazig, Sharqia Province, 002, Egypt

Location

MeSH Terms

Conditions

Epilepsy

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Study Officials

• nageeb rania, PI

  zagazig U

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: OTHER
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: April 18, 2019
• First Posted: April 24, 2019
• Study Start: June 1, 2018
• Primary Completion: January 30, 2019
• Study Completion: February 5, 2019
• Last Updated: April 24, 2019

Record last verified: 2019-04

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP
• Time Frame: after publishing the manuscript in the Egyptian journal of neurology, psychiatry and neurosurgery
• Access Criteria: after publishing the manuscript in the Egyptian journal of neurology, psychiatry and neurosurgery

Locations

EG (1)