Ventilatory Adaptation to Concentric Versus Eccentric Exercise in Patients With Severe COPD

NCT03923660 | Unknown

• 1 other identifier: P/2018/374
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Pulmonary rehabilitation (PR) based on concentric exercise training has become an integral component in the treatment of patients with chronic obstructive pulmonary disease (COPD), improving functional capacities while diminishing symptoms and improving quality of life. However, the response to concentric exercise training is heterogeneous from one COPD patient to another. The inability of some COPD patients to achieve the exercise intensities required to stress limb muscles due to severe ventilatory limitation could partially explain their poor response to training. Endurance exercise with eccentric muscle contractions could be an interesting alternative to concentric exercise because it produces greater muscle force through its lower metabolic cost. Eccentric exercise could allow patients with severe airflow limitation to perform prolonged exercise sessions with sufficient intensity to improve muscle function. Nevertheless, a recent study performed in healthy young subjects reported that eccentric exercise induced a more hyperpneic breathing pattern (i.e., lower tidal volume and higher breathing frequency) that concentric for a given minute ventilation. The main objective of CONvEX study is to compare ventilatory adaptation between two modalities of exercise performed on cycle ergometer (concentric versus eccentric) in severe COPD patients.

Conditions

Chronic Obstructive Pulmonary Disease Severe

Keywords

COPD; breathing pattern; exercise; concentric; eccentric

Outcome Measures

Primary Outcomes (1)

• Ventilatory adaptation

  Breathing frequency/tidal volume ratio at the maximum common minute ventilation.

  week 1

Secondary Outcomes (6)

• Dynamic hyperinflation

  week 1

• Brachial muscle enrollment

  week 1

• Quadriceps muscle enrollment

  week 1

• Ventilatory efficiency

  week 1

• Ventilatory efficiency

  week 1

Study Arms (2)

Concentric-eccentric

EXPERIMENTAL

Concentric-eccentric

Other: Incremental Concentric-eccentric exercise test

Eccentric-concentric

EXPERIMENTAL

Eccentric-concentric

Other: Incremental Eccentric-concentric exercise test

Interventions

Incremental Concentric-eccentric exercise test OTHER

Patients will perform incremental exercise test on semi recumbent eccentric ergometer

Concentric-eccentric

Incremental Eccentric-concentric exercise test OTHER

Patients will perform incremental exercise test on semi recumbent concentric ergometer

Eccentric-concentric

Eligibility Criteria

• Age: 40 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Severe COPD (FEV1 \[forced expiratory volume in 1 second\] / FVC \[forced vital capacity\] \< 70% et FEV1 \< 50%)
• Informed consent
• Affiliation to a social security scheme

You may not qualify if:

• Effort oxygen therapy
• Cardiovascular, neuromuscular or musculoskeletal disorders that can provide significant dyspnea or limit exercise
• Legal incapacity
• Low or no cooperation anticipated

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Besancon: lead

Study Sites (1)

CHU de Besançon

Besançon, 25000, France

Location

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive; Motor Activity

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 2, 2019
• First Posted: April 22, 2019
• Study Start: September 20, 2018
• Primary Completion: December 1, 2019
• Study Completion: December 1, 2019
• Last Updated: April 22, 2019

Record last verified: 2018-09

Locations

FR (1)