Single Nucleotide Polymorphisms (SNPs) Associated With Postoperative Analgesic Failure

NCT03916120 | Completed

• 1 other identifier: 2018-067
• Study Type: observational
• Target: 198
• Locations: 1 country
• Sites: 1

Brief Summary

Postoperative pain remains relatively high within 48h for Chinese patients who receive video-assisted thoracoscopic surgery. Different patients experience different pain intensity. This suggests that there may be genetic variants that make some patients susceptible to analgesic failure. Using blood samples from patients, the investigators are going to analyze the relationship between single nucleotide polymorphisms (SNPs) in genes that are known to be involved in analgesic failure.

Conditions

Pain, Postoperative; Thoracic Surgery, Video-Assisted; Polymorphism, Single Nucleotide

Outcome Measures

Primary Outcomes (1)

• Postoperative analgesic failure

  Once patient experience at least one of the following situations: 1. Bad patients sleep quality 2. Require extra analgesic drug 3. Low satisfaction with pain control 4. Bolus times \> 1 per hour

  8 a.m. at the first day after surgery.

Study Arms (2)

Postoperative Analgesic Failure

Genetic: Genetic analysis

Postoperative Analgesic Success

Genetic: Genetic analysis

Interventions

Genetic analysis GENETIC

Collect 2ml intravenous blood from patients after anaesthesia.

Postoperative Analgesic Failure; Postoperative Analgesic Success

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients receiving single-port video-assisted thoracoscopic surgery.

You may qualify if:

• Age ≤ 70 and Age ≥18
• Selective operation lung section with video-assisted thoracic surgery (VATS)
• III ≥ American Society of Anesthesiologists classification (ASA classification) ≥I
• Patients informed and agreed to join the study

You may not qualify if:

• Abnormal function of liver and kidney
• Allergic- dependence history of alcohol, opioids and Local anesthetics
• No noncompliance
• Mental disease history，language communication disorder，cicatricial diathesis
• Underweight or overweight（BMI\<18 or \>30)
• Patients not suitable for clinical subjects for other reasons
• Sedatives, analgesics, antiemetic drugs and anti pruritus drugs were used within 24hours before the operation.
• History of previous abnormal anaesthesia
• Women during pregnancy or lactation

Sponsors & Collaborators

• Second Affiliated Hospital, School of Medicine, Zhejiang University: lead

Study Sites (1)

The second affiliated hospital of Zhejiang University

Hangzhou, Zhejiang, 310000, China

Location

Related Publications (1)

• Xing X, Bai Y, Sun K, Yan M. Single nucleotide polymorphisms associated with postoperative inadequate analgesia after single-port VATS in Chinese population. BMC Anesthesiol. 2020 Feb 5;20(1):38. doi: 10.1186/s12871-020-0949-6.

  PMID: 32024468 DERIVED

MeSH Terms

Conditions

Pain, Postoperative

Interventions

Genetic Testing

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Investigative Techniques; Genetic Techniques; Genetic Services; Health Services; Health Care Facilities Workforce and Services; Diagnostic Services; Preventive Health Services

Study Officials

• Min Min, Doctor

  Zhejiang University

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 8, 2019
• First Posted: April 16, 2019
• Study Start: July 15, 2018
• Primary Completion: January 15, 2019
• Study Completion: January 15, 2019
• Last Updated: April 16, 2019

Record last verified: 2019-04

Locations

CN (1)