Role of Senescence in the Development of Endometrial Cancer

NCT03338985 | Unknown

• 1 other identifier: PA17002
• Study Type: interventional
• Target: 140
• Locations: 1 country
• Sites: 1

Brief Summary

Several molecular studies showed chromosomal alterations in patients with endometrial cancer, with gains in 1q, 19p, 19q, 8q, 10q and 10p and loss of 4q, 16q and 18q. Several genes of interest have been identified (P53, PTEN, PIK3CA, ß-catenin, K-ras ...). A study has already been carried out at the Reims University Hospital with inclusion of patients with endometrial cancer and patients with endometrial hyperplasia. It identified specific alterations of nosologic continuum of pathology and characterize areas of interest on the genome.

Conditions

Endometrial Hyperplasia and Endometrial Cancers

Outcome Measures

Primary Outcomes (1)

• Genetic imbalances

  Genetic aberrations detected by comparative genomic hybridization (CGH arry)

  Day 0

Study Arms (1)

Group "cases patients"

EXPERIMENTAL

patients with endometrial hyperplasia or endometrial cancers

Genetic: Genetic analysis

Interventions

Genetic analysis GENETIC

Genetic analysis of the samples taken during the surgery (hysterectomy or curettage resection) using CGH array technique.

Group "cases patients"

Eligibility Criteria

• Age: 18 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• patient with endometrial hyperplasia or endometrial cancer
• patient consenting to participate to the study
• patient enrolled in the national healthcare insurance program
• patient older than 18 years

You may not qualify if:

• \- patient with neoadjuvant chemotherapy or radiotherapy prior to surgery

Sponsors & Collaborators

• CHU de Reims: lead

Study Sites (1)

Damien JOLLY

Reims, France

RECRUITING

MeSH Terms

Conditions

Endometrial Hyperplasia; Endometrial Neoplasms

Interventions

Genetic Testing

Condition Hierarchy (Ancestors)

Uterine Diseases; Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Diseases; Uterine Neoplasms; Genital Neoplasms, Female; Urogenital Neoplasms; Neoplasms by Site; Neoplasms

Intervention Hierarchy (Ancestors)

Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Investigative Techniques; Genetic Techniques; Genetic Services; Health Services; Health Care Facilities Workforce and Services; Diagnostic Services; Preventive Health Services

Central Study Contacts

Emilie RAIMOND

CONTACT

0326789598; eraimond@chu-reims.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 8, 2017
• First Posted: November 9, 2017
• Study Start: October 16, 2017
• Primary Completion: October 16, 2019
• Study Completion: April 16, 2020
• Last Updated: January 5, 2018

Record last verified: 2018-01

Locations

FR (1)