NCT03913546

Brief Summary

The present study aims to assess the effects of spinal manipulation therapy on neuromuscular performance.

Trial Health

30
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Timeline
Completed

Started Jun 2022

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
withdrawn

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

April 4, 2019

Completed
8 days until next milestone

First Posted

Study publicly available on registry

April 12, 2019

Completed
3.1 years until next milestone

Study Start

First participant enrolled

June 1, 2022

Completed
1 month until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2022

Completed
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2022

Completed
Last Updated

May 13, 2024

Status Verified

May 1, 2024

Enrollment Period

1 month

First QC Date

April 4, 2019

Last Update Submit

May 10, 2024

Conditions

Keywords

neuromuscular propertiesstrengthpowerperformance

Outcome Measures

Primary Outcomes (4)

  • Maximal force

    Peak force registered during an isometric maximal voluntary contraction of the knee extensors.

    On the control session and on the intervention session (immediately after the sham or actual SMT procedure)

  • Voluntary activation

    Electromyographic activity of the vastus lateralis muscle registered during an isometric maximal voluntary contraction of the knee extensors.

    On the control session and on the intervention session (immediately after the sham or actual SMT procedure)

  • Peak power

    Peak power registered during a 30-second Wingate anaerobic cycling test

    On the control session and on the intervention session (immediately after the sham or actual SMT procedure)

  • Mean power

    Mean power registered during a 30-second Wingate anaerobic cycling test

    On the control session and on the intervention session (immediately after the sham or actual SMT procedure)

Study Arms (2)

Sham spinal manipulation

SHAM COMPARATOR

Participants in the 'sham' group will receive a sham mechanical thrust (force set at level 0) instead of an actual one. In the force level 0, no excursion of the stylus occurs, but the instrument produces the same clicking sound as in the actual SMT condition. Therefore, the subject does not distinguish between intervention or placebo.

Other: Sham spinal manipulative therapy

Actual spinal manipulation

EXPERIMENTAL

Participants in the actual actual spinal manipulative therapy (SMT) group will be assessed through the Activator basic method. SMT will be performed with the Activator IV Adjusting Instrument (Activator Methods International, Phoenix, AZ) varying the force level depending on the adjusted segment.

Procedure: Spinal manipulative therapy

Interventions

Participants in the actual spinal manipulative therapy group will be assessed through the activator basic method protocol. SMT will be performed with an Activator IV (Activator Methods International, Phoenix, AZ) setting the force at level 3 for the low thoracic spine (T7-T12), and level 4 for the lumbar spine and pelvis.

Also known as: Chiropractic manipulation, Spine thrust manipulation
Actual spinal manipulation

Participants in the sham SMT group will undergo a protocol identical to the actual one, with the exception that a sham mechanical thrust (force set at level 0) will be delivered to the targeted areas. In the force level 0 no excursion of the stylus occurs, but the instrument produces the same clicking sound as in the actual SMT condition

Sham spinal manipulation

Eligibility Criteria

Age18 Years - 45 Years
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Will be recruited from three different local triathlon and cycling clubs.
  • Will have to cycle at least 4 hours per week during the preceding 3 months, and to have a cycling experience greater than 2 years

You may not qualify if:

  • Having suffered an injury in the month before the study that precluded regular exercise practice
  • Having suffered any type of spine injury before the study
  • Having previously received Spinal Manipulation Therapy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Alcalá

Alcalá de Henares, 28871, Spain

Location

Related Publications (1)

  • Valenzuela PL, Pancorbo S, Lucia A, Germain F. Spinal Manipulative Therapy Effects in Autonomic Regulation and Exercise Performance in Recreational Healthy Athletes: A Randomized Controlled Trial. Spine (Phila Pa 1976). 2019 May 1;44(9):609-614. doi: 10.1097/BRS.0000000000002908.

    PMID: 30325889BACKGROUND

MeSH Terms

Interventions

Manipulation, Chiropractic

Intervention Hierarchy (Ancestors)

Musculoskeletal ManipulationsComplementary TherapiesTherapeutics

Study Officials

  • Pedro de la Villa, MD, PhD

    University of Alcalá

    STUDY DIRECTOR
0

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
TRIPLE
Who Masked
PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
Masking Details
Participants will receive either a sham procedure or the actual intervention. The researchers in charge of outcome assessment and statistical analysis will be blinded to the allocation of participants.
Purpose
OTHER
Intervention Model
PARALLEL
Model Details: Randomized, parallel, pre-post study design.
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate professor

Study Record Dates

First Submitted

April 4, 2019

First Posted

April 12, 2019

Study Start

June 1, 2022

Primary Completion

July 1, 2022

Study Completion

October 1, 2022

Last Updated

May 13, 2024

Record last verified: 2024-05

Locations