Low-frequency High-Intensity Interval Training in Overweight or Obese Young Adults

NCT03904810 | Completed

• 1 other identifier: HIIT001
• Study Type: interventional
• Target: 103
• Locations: 1 country
• Sites: 1

Brief Summary

Background: The relationship between the frequency of high-intensity interval training (HIIT) and the resultant adaptations is largely unclear. Purpose: This study examined the effects of different frequencies of HIIT compared to moderate-intensity continuous training (MICT) on body composition and cardiovascular biomarkers in overweight or obese adults. Methods: This study was a randomized, controlled, single-blinded trial. Fifty-six overweight or obese men aged between 18 and 30 years were randomly assigned to no-intervention control (CON; n=14), MICT performed thrice weekly (MICT×3/wk; n=9), HIIT performed thrice weekly (HIIT×3/wk; n=14), HIIT performed twice weekly (HIIT×2/wk; n=10), and HIIT performed once weekly (HIIT×1/wk; n=9). Each HIIT session consisted of 12 × 1-min bouts at 90% heart rate reserve (HRR), interspersed with 11 × 1-min bouts at 70% HRR (HIIT×3/wk: 69 min/wk; HIIT×2/wk: 46 min/wk; HIIT×1/wk: 23 min/wk). Aerobic capacity, resting heart rate, body composition, waist circumference, blood pressure, endothelial function, fasting blood glucose and lipids, circulatory adipokines and inflammatory biomarkers were examined at baseline, after 4 weeks and 8 weeks of intervention.

Conditions

Overweight and Obesity

Keywords

HIIT; Exercise frequency; Exercise intensity

Outcome Measures

Primary Outcomes (11)

• Estimated maximal oxygen consumption

  Estimated maximal oxygen consumption achieved during the 20-meter shuttle multistage run test were used for the assessment of aerobic fitness Unit: body weight, estimated oxygen consumption and minute will be combined to report the estimated VO2max in ml/kg/min.

  8 weeks

• Total running distance

  Total running distance in meters achieved during the 20-meter shuttle multistage run test were used for the assessment of aerobic fitness

  8 weeks

• Total body fat percentage

  Total body fat percentage were assessed by a bioelectrical impedance analyzer (BC-418, Tanita, Japan).

  8 weeks

• Total body fat mass

  Total body fat mass in kg were assessed by a bioelectrical impedance analyzer (BC-418, Tanita, Japan).

  8 weeks

• Total body fat-free mass percentage

  Total body fat-free mass percentage were assessed by a bioelectrical impedance analyzer (BC-418, Tanita, Japan).

  8 weeks

• Total fat-free mass

  Total body fat-free mass were assessed by a bioelectrical impedance analyzer (BC-418, Tanita, Japan).

  8 weeks

• Trunk fat mass

  Trunk fat mass in kg were assessed by a bioelectrical impedance analyzer (BC-418, Tanita, Japan).

  8 weeks

• Body weight

  Body weight in kg were assessed by a bioelectrical impedance analyzer (BC-418, Tanita, Japan).

  8 weeks

• Body height

  Body height in meter were assessed.

  8 weeks

• Body mass index (BMI)

  Weight and height will be combined to report BMI in kg/m\^2

  8 weeks

• Waist circumference

  Waist circumference was determined to the nearest 0.1 cm of a contact tension tape. The tape was applied directly to the skin at the mid-point between the lower margin of the last palpable rib and the top of the iliac crest.

  8 weeks

Secondary Outcomes (16)

• Systolic blood pressure

  8 weeks

• Diastolic blood pressure

  8 weeks

• Mean arterial pressure

  8 weeks

• Resting heart rate

  8 weeks

• Endothelial function

  8 weeks

Study Arms (5)

Control

NO INTERVENTION

Subjects in this group do not received any intervention

Moderate Intensity Continuous Training ×3/wk

ACTIVE COMPARATOR

Subjects in this group will receive three sessions of Moderate-Intensity Continuous Training per week throughout the 8 weeks experimental period

Behavioral: Exercise intervention

High Intensity Interval Training×3/wk

ACTIVE COMPARATOR

Subjects in this group will receive three sessions of High-Intensity Interval Training per week throughout the 8 weeks experimental period

Behavioral: Exercise intervention

High Intensity Interval Training×2/wk

ACTIVE COMPARATOR

Subjects in this group will receive two session of High-Intensity Interval Training per week throughout the 8 weeks experimental period

Behavioral: Exercise intervention

High Intensity Interval Training×1/wk

ACTIVE COMPARATOR

Subjects in this group will receive one session of High-Intensity Interval Training per week throughout the 8 weeks experimental period

Behavioral: Exercise intervention

Interventions

Exercise intervention BEHAVIORAL

HIIT groups performed 30-meter shuttle runs on a rooftop covered field whereas MICT group ran on a footpath with an overall flat and non-slippery road surface. All training sessions were preceded by a 5-minute self-pace warm-up jogging and ended with a 5-minute self-pace jogging or walking cool-down. Each session of MICT consisted of 30 minutes of continuous exercise at an intensity of 60% of heart rate reserve (HRR); \[i.e., (maximal HR - resting HR) × intensity + resting HR\]. For each HIIT session, the intensity was set at 90% HRR for high-intensity bouts, interspersed with active recovery at 70% HRR. All exercise sessions were supervised by qualified athletic coach or strength and conditioning coach.

High Intensity Interval Training×1/wk; High Intensity Interval Training×2/wk; High Intensity Interval Training×3/wk; Moderate Intensity Continuous Training ×3/wk

Eligibility Criteria

• Age: 18 Years - 30 Years
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Chinese male
• Aged 18-30 years
• Overweight or obesity, defined as BMI ≥23 kg/m2 (classification of overweight for Hong Kong adults according to Department of Health, Hong Kong SAR Government)

You may not qualify if:

• Chronic medical and health condition such as cardiovascular diseases, diabetes, neurological disease, musculoskeletal disorder, cancers, and autoimmune diseases
• Hypertension (blood pressure \>140/90 mmHg)
• Contraindications to participating in physical exercise
• Any pre-existing medical or physical issues that affected the experimental test
• Physically active (i.e., \>3 hours of moderate-intensity exercise weekly)
• Lean overweight population (BMI ≥23 kg/m2, but percent body fat ≤20%) according to the BMI data corresponding to bioelectrical impedance estimated percent body fat cut-off value among Hong Kong Chinese adults.

Sponsors & Collaborators

• The University of Hong Kong: lead

Study Sites (1)

LKS Faculty of Medicine

Hong Kong, Hong Kong

Location

MeSH Terms

Conditions

Overweight; Obesity

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate professor

Model Details: 5 groups ×3 times factorial design

Study Record Dates

• First Submitted: March 31, 2019
• First Posted: April 5, 2019
• Study Start: October 1, 2016
• Primary Completion: August 31, 2017
• Study Completion: August 31, 2017
• Last Updated: April 5, 2019

Record last verified: 2019-04

Data Sharing

• IPD Sharing: Will not share

Locations

HK (1)