Effect of High-intensity Interval Training on Metabolic Fitness in Overweight Males.

NCT02798666 | Completed

• 1 other identifier: CALIN-001
• Study Type: interventional
• Target: 16
• Locations: 0 countries
• Sites: N/A

Brief Summary

Background and aims: The purpose of this study was to evaluate the effect of high intensity interval training (HIIT) on body composition, physical fitness, metabolic fitness and muscle histology in men with overweight or obesity compared to continuous aerobic training (CAT). Material and methods: 16 male participants with overweight/obesity (age range: 42 - 57 years, body mass index: 28 - 36 kg/m²) were randomized to HITT (n=8) or CAT (n=8). HIIT was composed of two sprint blocks of 10 minutes at ventilatory threshold (VT), within between a continuous block of 10 minutes, twice a week for 15 weeks. CAT was composed of three blocks of 10 minutes continuous endurance training at VT. After 5 weeks, intensity was increased to 110% of VT. Changes in body composition, physical fitness (peakVO2 and anaerobic threshold (AT)), basal respiratory exchange ratio (bRER) and insulin sensitivity by oral glucose tolerance test were evaluated. Mitochondrial content was evaluated by transmission electron microscopy (TEM) in muscle biopsies.

Conditions

Overweight and Obesity

Keywords

Physical fitness; Respiratory exchange ratio; Insulin sensitivity; High intensity interval training; Continuous exercise training

Outcome Measures

Primary Outcomes (1)

• Insulin sensitivity measured by oral glucose tolerance test

  Baseline and 10 weeks (end of intervention)

Secondary Outcomes (5)

• Respiratory exchange ratio measured by ergospirometry at rest

  Baseline and 10 weeks (end of intervention)

• muscle fiber fat content measured by transmission electron microscopy in muscle biopsy

  Baseline and 10 weeks (end of intervention)

• muscle fiber mitochondrial content measured by transmission electron microscopy in muscle biopsy

  Baseline and 10 weeks (end of intervention)

• PeakVO2 measured by ergospirometry during maximal exercise testing

  Baseline and 10 weeks (end of intervention)

• Ventilatory threshold measured by ergospirometry during maximal exercise testing

  Baseline and 10 weeks (end of intervention)

Other Outcomes (3)

• Weight measured by weight scale

  Baseline and 10 weeks (end of intervention)

• Heigth measured by stadiometer

  Baseline and 10 weeks (end of intervention)

• BMI

  Baseline and 10 weeks (end of intervention)

Study Arms (2)

High intensity exercise training

EXPERIMENTAL

The participants exercised for 40 minutes, twice a week, under supervision of two physiotherapists for in total 10 weeks. Each training session included a warming up, a sprint interval block \[10 minutes\], continuous aerobic exercise \[10 minutes\], another sprint interval block \[10 minutes\] and cooling down. For the first 5 weeks, each sprint interval block consisted of 10 sprint bouts \[\>100 r/min\] of 15 seconds at a cycling resistance matching with the ventilatory threshold \[VTR\], alternated with 45 seconds relative rest \[50 r/min at VTR\]. Starting from week 6 until week 10, the intensity of sprinting and relative rest was increased up to 110% of VTR.

Other: High intensity exercise training

Continuous exercise training

ACTIVE COMPARATOR

The comparative group performed a continuous aerobic training \[CAT\] for 10 weeks, twice a week and 40 minutes per session \[volume and frequency is equal to HIIT\]. The protocol of the CAT group consisted of warming up \[stretching of the large muscle groups and cardiovascular exercises at 30% of peak cycling power output for five minutes\], continuous aerobic exercise training \[3 times 10 minutes\] and cooling down \[stretching of the large muscle groups and cardiovascular exercises at 30% of peak cycling power output for five minutes\]. During the continuous aerobic protocol \[cycling or stepping\] participants exercised for 10 minutes at a HR similar to the HR at VT \[60 r/min\], which was increased to 110% of VT from week 6 onwards.

Other: Continuous exercise training

Interventions

High intensity exercise training OTHER

Exercise training using sprint interval exercise

Also known as: HIT

High intensity exercise training

Continuous exercise training OTHER

Exercise training using continuous exercise at constant heart rate

Also known as: CAT

Continuous exercise training

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• BMI between 27 and 35

You may not qualify if:

• Diabetes (HbA1c\>6,5%),
• severe musculoskeletal (eg osteoarthritis),
• cardiovascular (eg chronic heart failure) or respiratory (eg chronic obstructive pulmonary disease (COPD)) problems based on medical files.

Sponsors & Collaborators

• University Ghent: lead

Related Publications (1)

• Cochran AJ, Percival ME, Tricarico S, Little JP, Cermak N, Gillen JB, Tarnopolsky MA, Gibala MJ. Intermittent and continuous high-intensity exercise training induce similar acute but different chronic muscle adaptations. Exp Physiol. 2014 May 1;99(5):782-91. doi: 10.1113/expphysiol.2013.077453. Epub 2014 Feb 14.

  PMID: 24532598 RESULT

MeSH Terms

Conditions

Overweight; Obesity; Insulin Resistance

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases

Study Officials

• Patrick Calders, Professor

  Department of Rehabilitation Sciences and Physiotherapy, Universtity of Ghent

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 31, 2016
• First Posted: June 14, 2016
• Study Start: June 1, 2015
• Primary Completion: December 1, 2015
• Study Completion: December 1, 2015
• Last Updated: December 18, 2023

Record last verified: 2023-12

Data Sharing

• IPD Sharing: Will not share