Quantification of Ketosis After Intake of Coconut Oil and Caprylic Acid-With and Without Glucose-After a 12-hour Fast

NCT03904433 | Completed

• 1 other identifier: CC1
• Study Type: interventional
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

In a cross-over design, 15 participants, age 65-75, will be tested in six different arms in a randomised order. After a 12-hour fast participants will be served 2.5 dl coffee with 15 g cream + 30-50 g of different fatty acids, with or without 50 g glucose. Blood ketones and other biomarkers will be measured during 4 hours.

Conditions

Aged

Outcome Measures

Primary Outcomes (1)

• Concentrations of BHB, area under the curve, 0-4 h

  BHB, measured in venous whole blood with a point-of-care meter

  0, 15, 30, 45, 60, 75, 90, 120, 150, 180, 210, 240 (minutes)

Secondary Outcomes (6)

• Concentrations of total ketones

  0, 30, 60, 120 (minutes)

• Concentrations of BHB (capillary)

  30, 60, 120 (minutes)

• Concentrations of BDNF / pro-BDNF

  0, 60, 120, 240 (minutes)

• Concentrations of glucose

  0, 60, 120, 180, 240 (minutes)

• Self-rated satiety

  240 (minutes)

Other Outcomes (3)

• Concentrations of insulin

  0, 60, 90, 120, 240 (minutes)

• Concentrations of glucagon

  0, 60, 90, 120, 240 (minutes)

• Concentrations of HbA1c

  0 (minutes)

Study Arms (6)

1. Sunflower oil

EXPERIMENTAL

Sunflower oil (30 g)

Other: Sunflower oil

2. Caprylic acid

EXPERIMENTAL

Caprylic acid (20 g) + Sunflower oil (10 g)

Dietary Supplement: Caprylic acid; Other: Sunflower oil

3. Caprylic acid + Glucose

EXPERIMENTAL

Caprylic acid (20 g) + Sunflower oil (10 g) + Glucose (50 g)

Dietary Supplement: Caprylic acid; Other: Sunflower oil; Other: Glucose

4. Coconut oil

EXPERIMENTAL

Coconut oil (30 g)

Other: Coconut oil

5. Coconut oil + Glucose

EXPERIMENTAL

Coconut oil (30 g) + Glucose (50 g)

Other: Coconut oil; Other: Glucose

6. Coconut oil + Caprylic acid

EXPERIMENTAL

Coconut oil (30 g) + Caprylic acid (20 g)

Other: Coconut oil; Dietary Supplement: Caprylic acid

Interventions

Coconut oil OTHER

Coconut oil given in coffee with cream

4. Coconut oil; 5. Coconut oil + Glucose; 6. Coconut oil + Caprylic acid

Caprylic acid DIETARY_SUPPLEMENT

Caprylic acid given in coffee with cream

2. Caprylic acid; 3. Caprylic acid + Glucose; 6. Coconut oil + Caprylic acid

Sunflower oil OTHER

Sunflower oil given in coffee with cream

1. Sunflower oil; 2. Caprylic acid; 3. Caprylic acid + Glucose

Glucose OTHER

Glucose dissolved in water

3. Caprylic acid + Glucose; 5. Coconut oil + Glucose

Eligibility Criteria

• Age: 65 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)

You may qualify if:

• Daily consumption of coffee
• Written informed consent

You may not qualify if:

• Smoker
• Weight \<50 kg
• Diagnosed diabetes
• History of heart disease
• History of disease related to internal organs or metabolism
• Experience of "sensitive gut", or known intolerance to the test ingredients
• Medication expected to affect glucose- or lipid-metabolism
• Fasting during study or one month before
• High intensity physical activity \> 3 times/week
• Dementia
• Severe psychiatric conditions
• Hb\<125 g/L
• Participation in other lifestyle intervention last 6 months

Sponsors & Collaborators

• Karolinska Institutet: lead

Study Sites (1)

Karolinska Institutet

Solna, Stockholm County, 17176, Sweden

Location

Related Publications (2)

• Norgren J, Daniilidou M, Kareholt I, Sindi S, Akenine U, Nordin K, Rosenborg S, Ngandu T, Kivipelto M, Sandebring-Matton A. Serum proBDNF Is Associated With Changes in the Ketone Body beta-Hydroxybutyrate and Shows Superior Repeatability Over Mature BDNF: Secondary Outcomes From a Cross-Over Trial in Healthy Older Adults. Front Aging Neurosci. 2021 Aug 20;13:716594. doi: 10.3389/fnagi.2021.716594. eCollection 2021.

  PMID: 34489682 DERIVED

• Norgren J, Sindi S, Sandebring-Matton A, Kareholt I, Daniilidou M, Akenine U, Nordin K, Rosenborg S, Ngandu T, Kivipelto M. Ketosis After Intake of Coconut Oil and Caprylic Acid-With and Without Glucose: A Cross-Over Study in Healthy Older Adults. Front Nutr. 2020 Apr 15;7:40. doi: 10.3389/fnut.2020.00040. eCollection 2020.

  PMID: 32351966 DERIVED

MeSH Terms

Interventions

Coconut Oil; octanoic acid; Sunflower Oil; Glucose

Intervention Hierarchy (Ancestors)

Dietary Fats; Fats; Lipids; Plant Oils; Oils; Plant Preparations; Biological Products; Complex Mixtures; Hexoses; Monosaccharides; Sugars; Carbohydrates

Study Officials

• Miia Kivipelto, Professor

  Karolinska Institutet

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor, MD, PhD

Study Record Dates

• First Submitted: April 3, 2019
• First Posted: April 5, 2019
• Study Start: August 24, 2018
• Primary Completion: October 12, 2018
• Study Completion: October 12, 2018
• Last Updated: May 3, 2019

Record last verified: 2019-04

Locations

SE (1)