Effects of A-GPC on Reaction Time and Cognitive Function

NCT03903250 | Completed

• 1 other identifier: AGPC-1
• Study Type: interventional
• Target: 18
• Locations: 1 country
• Sites: 1

Brief Summary

This is a randomized, double blind, crossover design study which measures the effect of alpha-glycerylphosphorylcholine (A-GPC) on reaction time and cognitive function in non-resistance trained males and females. Participants will complete baseline testing and then be randomized into one of two crossover treatments. Participants will report to the lab for five consecutive days whilst only getting a maximum of five hours of sleep per night from Monday through Thursday night. Once testing is complete on Friday, participants will receive a one week washout period then return to complete the opposite treatment.

Conditions

Cognitive Change; Reaction Time

Keywords

A-GPC; focus; non-resistance trained

Outcome Measures

Primary Outcomes (3)

• Effects of A-GPC on Reaction Time

  The primary purpose of this investigation is to determine the effectiveness of alpha-glycerylphosphorylcholine (A-GPC) on changes in reaction time in young, non-resistance trained males and females. This will be accomplished by observing changes in reaction time via the Makoto Arena. The Makoto Arena is an instrument that utilizes lights and noises to assess reaction time. Participants are required to hit the lights when they appear on the tower as fast as possible. Participants are instructed to hit as many lights as fast as possible to acquire a score that consists of the following: number of targets hit, number of targets that appeared, average reaction time, and percentage of targets hit.

  within 5 days

• Effects of A-GPC on Mental Alertness

  The primary purpose of this investigation is to determine the effectiveness of alpha-glycerylphosphorylcholine (A-GPC) on changes in mental alertness in young, non-resistance trained males and females. This will be accomplished by observing changes in ImPACT test scores before and after acute exercise, and after 4 days of sleep deprivation defined as only 5 hours of sleep per night. The ImPACT test measures cognitive function via the following tests: verbal memory, visual memory, symbol matching, color matching, and a three letter sequence memory test. For the verbal and visual memory tests, a composite score is taken between 0-100 with 100 indicating best cognitive performance and 0 indicating the worst cognitive performance. For the symbol matching and color matching, a visual motor composite score is taken from 0-60 with 60 indicating the best cognitive performance and 0 indicating the worst cognitive performance.

  within 5 days

• Effects of A-GPC on Mental Fatigue

  The primary purpose of this investigation is to determine the effectiveness of alpha-glycerylphosphorylcholine (A-GPC) on changes in mental fatigue in young, non-resistance trained males and females. This will be accomplished by observing changes in ImPACT test scores before and after acute exercise, and after 4 days of sleep deprivation defined as only 5 hours of sleep per night. The ImPACT test measures cognitive function via the following tests: verbal memory, visual memory, symbol matching, color matching, and a three letter sequence memory test. For the verbal and visual memory tests, a composite score is taken between 0-100 with 100 indicating best cognitive performance and 0 indicating the worst cognitive performance. For the symbol matching and color matching, a visual motor composite score is taken from 0-60 with 60 indicating the best cognitive performance and 0 indicating the worst cognitive performance.

  within 5 days

Study Arms (2)

Sugar

PLACEBO COMPARATOR

100% soluble in liquid. 4 oz. taken in the morning of testing sessions.

Dietary Supplement: Sugar

A-GPC

EXPERIMENTAL

100% soluble in liquid. 4 oz. taken in the morning of testing sessions.

Dietary Supplement: A-GPC

Interventions

A-GPC DIETARY_SUPPLEMENT

Taken orally in liquid form

A-GPC

Sugar DIETARY_SUPPLEMENT

Taken orally in liquid form

Sugar

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Participants will be male or female between the ages of 18-35 years;
• Participants regularly sleep \>7.5 hours per night;
• Participants have not been consistently resistance training for the past 6 months;
• Participant has provided written and dated informed consent to participate in the study;
• Participant is willing and able to comply with the protocol;
• Participant is apparently healthy and free from disease, as determined by a health history questionnaire;
• Participants agrees to not drive or operate heavy machinery while under sleep deprivation as a result of the study (Tuesday-Saturday);

You may not qualify if:

• Participant currently smokes or have quit within the last 6 months;
• Participant is medically prescribed by a physician to take over the counter medications including medications related to insomnia or sleep aids (such as melatonin);
• Participant is medically diagnosed with a mental health/psychological disorder or suspected of having a mental health/diagnostic disorder that would be influenced or made worse by sleep deprivation;
• Participant is allergic to any ingredient in the nutritional supplement or placebo;
• Participant may be pregnant, is pregnant, is trying to become pregnant, or is breastfeeding;
• Participant has a major exam or academic requirement that will fall during the sleep deprived portion of the study (Tuesday-Friday)
• Participant reports any unusual adverse events associated with this study that in consultation with the study investigators or their doctor recommends removal from the study;
• Participants fail to abstain from operating motor vehicles or heavy machinery;

Sponsors & Collaborators

• University of Mary Hardin-Baylor: lead
• Chemi Nutra, LLC.: collaborator

Study Sites (1)

UMHB Human Performance Lab

Belton, Texas, 76513, United States

Location

MeSH Terms

Interventions

Sugars

Intervention Hierarchy (Ancestors)

Carbohydrates

Study Officials

• Lemuel W Taylor IV, PhD

  UMHB Human Performance Lab

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Two groups: placebo and active

Study Record Dates

• First Submitted: April 2, 2019
• First Posted: April 4, 2019
• Study Start: March 25, 2019
• Primary Completion: September 18, 2020
• Study Completion: September 18, 2020
• Last Updated: November 12, 2020

Record last verified: 2020-11

Locations

US (1)