NCT03869489

Brief Summary

The purpose of this study is to determine whether anodal transcranial direct current stimulation (tDCS) applied to the left dorsolateral prefrontal cortex induces approach motivation, and whether anodal tDCS applied to the right dorsolateral prefrontal cortex induces avoidance motivation. This study consists of three experiments: one in which an approach/avoidance video game is validated, one in which the effect of anger and fear on approach/avoidance is studied, and one in which the effect of tDCS is studied. Only the experiment in which the effect of tDCS is studied involves tDCS.

Trial Health

30
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Timeline
Completed

Started Nov 2019

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
withdrawn

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 8, 2019

Completed
3 days until next milestone

First Posted

Study publicly available on registry

March 11, 2019

Completed
8 months until next milestone

Study Start

First participant enrolled

November 1, 2019

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2020

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2020

Completed
Last Updated

September 4, 2019

Status Verified

August 1, 2019

Enrollment Period

5 months

First QC Date

March 8, 2019

Last Update Submit

August 30, 2019

Conditions

Keywords

approach motivationavoidance motivationtranscranial direct current stimulation

Outcome Measures

Primary Outcomes (1)

  • Avoidance-Approach time difference

    Median of the difference between time to approach and time to avoid a stimulus

    1 year

Study Arms (3)

Anodal left dorsolateral prefrontal cortex tDCS stimulation

EXPERIMENTAL
Device: Anodal left dorsolateral prefrontal cortex tDCS stimulation

Anodal right dorsolateral prefrontal cortex tDCS stimulation

EXPERIMENTAL
Device: Anodal right dorsolateral prefrontal cortex tDCS stimulation

Sham tDCS stimulation

SHAM COMPARATOR
Device: Sham tDCS stimulation

Interventions

Anodal tDCS will be applied to the left dorsolateral prefrontal cortex of participants

Anodal left dorsolateral prefrontal cortex tDCS stimulation

Anodal tDCS will be applied to the right dorsolateral prefrontal cortex of participants

Anodal right dorsolateral prefrontal cortex tDCS stimulation

Sham tDCS stimulation will be applied

Sham tDCS stimulation

Eligibility Criteria

Age18 Years - 35 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Normal hearing and vision

You may not qualify if:

  • Left-handedness
  • History of seizure, head injury (including neurosurgery), brain injury, diagnosis or a neurological or psychiatric disorder, metal in the head, sensitive scalp
  • History of anxiolytic and/or antidepressant medications
  • Participation in Experiment #1 or Experiment #2 of the larger study

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Center for Applied Brain and Cognitive Sciences

Medford, Massachusetts, 02155, United States

Location
0

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
BASIC SCIENCE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 8, 2019

First Posted

March 11, 2019

Study Start

November 1, 2019

Primary Completion

April 1, 2020

Study Completion

April 1, 2020

Last Updated

September 4, 2019

Record last verified: 2019-08

Data Sharing

IPD Sharing
Will not share

N/A. Study withdrawn

Locations