Evaluation of Transcranial Doppler Vasoconstrictor Vasoreactivity During General Anesthesia in Hypertensive Patients

NCT03897790 | Withdrawn

• 2 other identifiers: RIPH3-RNI19-DiVADH2019-A00719-48
• Study Type: observational
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

During a general anesthesia, people over 65 years old and hypertensive, have a modification of the vasoreactivity and their cerebral blood flow under vasoconstrictor such as norepinephrine or phenylephrine. We study the variation of the average velocity of the average cerebral artery under vasoconstrictor and during a modification of End Tidal CO2 (EtCO2) by transcranial Doppler.

Conditions

Hypertensive Disease; Elderly; Vasopressors; General Anesthesia

Keywords

cerebral vasoreactivity; transcranial doppler; hypertensive disease; elderly; vasopressors; general anesthesia

Outcome Measures

Primary Outcomes (1)

• Variation of the velocity of the middle cerebral artery with vasoconstrictors and during a modification of EtCO2.

  Measurements from transcranial doppler velocity of the middle cerebral artery

  48 hours

Secondary Outcomes (1)

• Variation of cardiac output with vasoconstrictors and during modification of EtCO2.

  48 hours

Study Arms (1)

Patients under vasoconstrictor

Patients older than 65 years old and hypertensive, requiring vasoconstrictor (phenylephrine or Neosynephrine) during general anesthesia.

Other: Transcranial Doppler (DTC)

Interventions

Transcranial Doppler (DTC) OTHER

Evaluation of Vasoconstrictor Vasoreactivity with Transcranial Doppler

Patients under vasoconstrictor

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

population, older over 65 years and hypertensive blood pressure disease with general anesthesia in Tours Hospital in France.

You may qualify if:

• older over 65 years
• high blood pressure disease
• need general anesthesia
• need vasopressors : norepinephrine or phenylephrine
• temporal window of transcranial doppler is viable

You may not qualify if:

• Acute, valvular, rhythmic or ischemic cardiovascular pathology
• severe arthritis (stage 3)
• Intra-cranial pathology
• Significant carotid stenosis (\> 40%) or carotid endarterectomy
• Cervical surgery
• Taking a premedication that can modify cerebral vasoreactivity
• Insulin-dependent diabetes for more than 10 years
• Person under judicial protection
• Opposition to data processing

Sponsors & Collaborators

• University Hospital, Tours: lead

MeSH Terms

Conditions

Hypertension

Interventions

Ultrasonography, Doppler, Transcranial; Ditiocarb

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Echoencephalography; Neuroradiography; Neuroimaging; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Radiography; Ultrasonography; Ultrasonography, Doppler; Diagnostic Techniques, Neurological; Investigative Techniques; Thiocarbamates; Carbamates; Acids, Acyclic; Carboxylic Acids; Organic Chemicals; Sulfur Compounds

Study Officials

• Marc LAFFON, MD-PhD

  Univsersity Hospital, Tours

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 27, 2019
• First Posted: April 1, 2019
• Study Start: April 2, 2019
• Primary Completion: April 2, 2019
• Study Completion: April 2, 2019
• Last Updated: September 26, 2019

Record last verified: 2019-09