Ability of Carotid Sonography and Inferior Vena Cava Sonography for the Prediction of Post-induction Hypotension in Hypertensive Patients

NCT03986112 | Unknown

• 1 other identifier: 1-2018-0064
• Study Type: observational
• Target: 58
• Locations: 1 country
• Sites: 1

Brief Summary

Hypertensive patients have more hemodynamic instability during general anesthesia than do patients with NORMOTENSION. In this study, the investigators evaluated the usefulness of carotid ultrasound and inferior vena cervical ultrasound for predicting hypotension after induction of anesthesia in patients with hypertension.

Conditions

General Anesthesia

Keywords

carotid sonography; inferior vena cava sonography; hypertension; general anesthesia; predictive power

Outcome Measures

Primary Outcomes (8)

• Prediction power of the post-induction hypotension of carotid sonography and inferior vena cava sonography

  To evaluate the ability of carotid sonography and inferior vena cava sonography for the post-induction hypotension in hypertensive patients undergoing general anesthesia, blood pressure was measured 8 times below time points.

  Prior to induction

• Prediction power of the post-induction hypotension of carotid sonography and inferior vena cava sonography

  To evaluate the ability of carotid sonography and inferior vena cava sonography for the post-induction hypotension in hypertensive patients undergoing general anesthesia, blood pressure was measured 1 minute after anesthetic induction.

  1 minute after anesthetic induction

• Prediction power of the post-induction hypotension of carotid sonography and inferior vena cava sonography

  To evaluate the ability of carotid sonography and inferior vena cava sonography for the post-induction hypotension in hypertensive patients undergoing general anesthesia, blood pressure was measured Immediately after intubation.

  Immediately after intubation

• Prediction power of the post-induction hypotension of carotid sonography and inferior vena cava sonography

  To evaluate the ability of carotid sonography and inferior vena cava sonography for the post-induction hypotension in hypertensive patients undergoing general anesthesia, blood pressure was measured 1 minute after tracheal intubation.

  1 minute after tracheal intubation

• Prediction power of the post-induction hypotension of carotid sonography and inferior vena cava sonography

  To evaluate the ability of carotid sonography and inferior vena cava sonography for the post-induction hypotension in hypertensive patients undergoing general anesthesia, blood pressure was measured 3 minutes after tracheal intubation.

  3 minutes after tracheal intubation

• Prediction power of the post-induction hypotension of carotid sonography and inferior vena cava sonography

  To evaluate the ability of carotid sonography and inferior vena cava sonography for the post-induction hypotension in hypertensive patients undergoing general anesthesia, blood pressure was measured 5 minutes after tracheal intubation.

  5 minutes after tracheal intubation

• Prediction power of the post-induction hypotension of carotid sonography and inferior vena cava sonography

  To evaluate the ability of carotid sonography and inferior vena cava sonography for the post-induction hypotension in hypertensive patients undergoing general anesthesia, blood pressure was measured 7 minutes after tracheal intubation.

  7 minutes after tracheal intubation

• Prediction power of the post-induction hypotension of carotid sonography and inferior vena cava sonography

  To evaluate the ability of carotid sonography and inferior vena cava sonography for the post-induction hypotension in hypertensive patients undergoing general anesthesia, blood pressure was measured 10 minutes after tracheal intubation.

  10 minutes after tracheal intubation

Study Arms (1)

hypertensive group

Evaluation of the ability of carotid sonography and inferior vena cava sonography for the post-induction hypotension in hypertensive patients undergoing general anesthesia

Biological: carotid sonography and inferior vena cava sonography

Interventions

carotid sonography and inferior vena cava sonography BIOLOGICAL

Carotid and venous ultrasonography is performed in a comfortable state. Corrected blood flow after carotid ultrasound and carotid artery blood flow rate were measured. After inferior vena cava sonography, the collapsibility Index by measuring the largest and smallest diameter during the respiratory cycle will be obtained. Propofol 2 mg / kg is administered and remifentanil is maintained at 4.0 ng / mL using the Target Control System. Blood pressure and heart rate are measured at prior to induction, 1 minute after induction, immediately after intubation, and at 1, 3, 5, 7 and 10 minutes after intubation. Post-induction hypotension is considered as a decrease of 20% or more of baseline blood pressure or a mean arterial blood pressure of less than 60 mmHg. In the event of hypotension in accordance with the above definition, repeated administration of ephedrine 4 mg or phenylephrine 50 mcg is used.

hypertensive group

Eligibility Criteria

• Age: 19 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Hypertensive patients aged 19 to 80 years who are scheduled to undergo surgery under general anesthesia

You may qualify if:

• \) 19-80 years old hypertensive patients with ASA class I-III
• \) Scheduled surgery under general anesthesia

You may not qualify if:

• \) Emergency operation
• \) Reoperation
• \) Patients with history of heart failure (unstable angina, congestive heart failure, coronary artery disease)
• \) Patients under 40 % of Ejection faction
• \) Patients with history of valvular heart failure
• \) Patients with history of peripheral arterial occlusive disease
• \) Patients with history of arrhythmia (specially AV nodal block), ventricular conduction problem
• \) Pregnancy patients
• \) Patients who cannot read the consent form (examples: Illiterate, foreigner)
• \) Patients with history of uncontrolled psychiatric disease (PTSD, anxiety, depression)
• \) Patients who withdraw the consent

Sponsors & Collaborators

• Yonsei University: lead

Study Sites (1)

Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institue, Yonsei Universiy College of Medicine

Seoul, 03722, South Korea

Location

MeSH Terms

Conditions

Hypertension

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Central Study Contacts

So yeon Kim, MD

CONTACT

+82-10-8871-2786; knnyyy@yuhs.ac

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 12, 2019
• First Posted: June 14, 2019
• Study Start: July 1, 2019
• Primary Completion: May 1, 2020
• Study Completion: May 1, 2020
• Last Updated: June 17, 2019

Record last verified: 2019-06

Locations

KR (1)