Volume and pH of Gastric Contents in Patients Undergoing Gynecologic Laparoscopic Surgery During Emergence From General Anesthesia

NCT03672734 | Unknown DMC

• 1 other identifier: 328/2561(EC3)
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Complications during general anesthesia,induction period: difficult airway, hypotension, upper airway obstruction, laryngospasm, pulmonary aspiration Maintenance period: hypotension, hypertension, awareness, bronchospasm, pulmonary aspiration. Emergence period: delayed emergence, upper airway obstruction, pulmonary aspiration. Pulmonary aspiration occur all ranges of general anesthesia. Because the patients can not protected themselves due to anesthetic medication, example: volatile agent, opioid.This can cause decrease consciousness, delayed gastric emptying time. Incidence of pulmonary aspiration was 1 : 900 - 1 : 10,000 of general of anesthesia (induction 20%, emergence 80%), Anesthesia Service in Siriraj Hospital (2017) 6: 25,000 case Pathophysiology of pulmonary aspiration. Pulmonary aspiration is defined as inhalation of oropharynx or stomach contents through the larynx to low respiratory tract. Aspiration pneumonitis is the inflammation of the lung caused by aspirating or inhaling irritants (Mendelson's syndrome). Gastric acid is a digestive fluid formed in the stomach and is composed of hydrochloric acid, potassium chloride, and sodium chloride.The highest concentration of gastric acid is 140-160 mEq/L. The pH of gastric acid is 1.5-3.5 in the human stomach lumen. Risk factors for increased gastric contents: full stomach, delayed gastric emptying, incompetent lower esophageal sphincter, lithotomy position, laparoscopy, length of surgery more than 2 hr., difficult airway. This study observed Volume and pH of Gastric Contents in Patients undergoing Gynecologic Laparoscopic Surgery during Emergence from General Anesthesia.

Conditions

General Anesthesia

Keywords

pH gastric contents; laparoscopic surgery; pH stomach; volume gastric content

Outcome Measures

Primary Outcomes (1)

• pH of Gastric Contents

  After general anesthesia, the investigator will insert an orogastric tube to drain the all the gastric secretion until the end of surgery. The pH of the content will be measured at the end of the operation.

  6 hours

Secondary Outcomes (1)

• Volume of Gastric Content

  6 hours

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients underwent gynecologic laparoscopic surgery.

You may qualify if:

• ASA class 1-2,
• years old,
• Laparoscopic surgery,
• BMI\<30kg/sq.m.

You may not qualify if:

• Difficult inserted orogastric tube.

Sponsors & Collaborators

• Siriraj Hospital: lead

Study Sites (1)

Waerunee Boayam

Bangkok, 10700, Thailand

Location

Related Publications (16)

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Study Officials

• Warunede Buayam, B.NS

  Department of Anesthesiology, Faculty of Medicine, Siriraj hospital

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol university

Study Record Dates

• First Submitted: August 31, 2018
• First Posted: September 14, 2018
• Study Start: September 20, 2018
• Primary Completion: September 20, 2019
• Study Completion: December 31, 2019
• Last Updated: April 4, 2019

Record last verified: 2018-09

Data Sharing

• IPD Sharing: Will not share

Locations

TH (1)