Attentional Control

NCT03872999 | Completed

• 2 other identifiers: 69HCL19_01272019-A00713-54
• Study Type: interventional
• Target: 76
• Locations: 1 country
• Sites: 1

Brief Summary

The project is dedicated to understanding the integration within the brain of signals of different natures that contribute to attentional control. The investigator will make use of standardized experimental displays involving the discrimination of a target (tilted-bar) presented together with 3 distractor items, with one stimulus in each visual quadrant. Across three fMRI experiments in healthy participants, the investigator will manipulate different types of signals that will guide the subject's attention towards one of the four quadrants: Exp 1 - task instruction \& item salience; Exp 2 - probabilistic target location; Exp 3 - probabilistic reward. The investigator expects that irrespective of the nature of the control signal, activity in dorsal parietal cortex will index the currently relevant/attended location. Moreover, The investigator expects that upon changes of the most relevant location, one will observe activation of the ventral parietal cortex, plus increased inter-regional connectivity between ventral and dorsal parietal regions - again irrespective of the nature of the attention guiding signals.

Conditions

Attention Control; Healthy Volunteers

Keywords

Attention; Control; Functional Magnetic Resonance Imaging (fMRI); Parietal; Space

Outcome Measures

Primary Outcomes (1)

• Changes of hemodynamic response in dorsal parietal regions representing specific spatial locations (visual quadrants)

  After spatial pre-processing of individual series of functional magnetic resonance imaging (fMRI) scans, normalization and smoothing as suggested for Statistical Parametric Mapping (SPM) analysis, the different attentional conditions will be modeled and convolved with canonical Hemodynamic Response Function (HRF). The model will be estimated according to the algorithm of SPM. Using a Region of Interest (ROI) approach, the investigator will extract the signal in dorsal parietal regions representing the four visual quadrants, and will compare activity as a function of the attended / most relevant location. The main hypothesis will be confirmed by activation of the ROI corresponding to the currently attended location, irrespective of the nature of the signal guiding attention (i.e. common effects in Exp 1-3).

  Day 0

Secondary Outcomes (2)

• Evaluation of the brain hemodynamic response

  Day 0

• Evaluation of the connectivity of the ventral parietal cortex at the time when there is a change of the most relevant spatial location/visual quadrant. x²

  Day 0

Study Arms (1)

Attentional Control

EXPERIMENTAL

Visuo-spatial attentional tasks with simple stimuli during functional magnetic resonance imaging (fMRI) scanning.

Other: Functional brain imaging without any contrast agent

Interventions

Functional brain imaging without any contrast agent OTHER

During the functional magnetic resonance imaging (fMRI) protocol, the subject will perform the attentional task while whole-brain activity will be recorded using Echo Planar Imaging (EPI) that measures the Blood Oxygen Level Dependent (BOLD) signal (2x2x2 isotropic voxels, Echo Time (ET) = 30 ms, Repetition Time (RT) = 2.5 sec). The functional session will be subdivided into several parts ("Runs", duration: 10-15 min). Together with the functional data, the protocol will include a structural scan (T1 weighted, 1x1x1 mm voxels; duration 5-7 min) and a field mapping sequence (duration: 1 min).

Attentional Control

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Be 18 to 40 years old

You may not qualify if:

• Previous neurologic or psychiatric disease.
• Cognitive deficits restricting understanding of the tasks.
• Pregnant or breath-feeding women.
• Persons under guardianship, curator or any other administrative or judicial measure of deprivation of rights or liberty.
• Subjects currently participating in other study.
• Neurologic, cardiac electrostimulation or defibrillator.
• Cardiac prostheses
• Intracranial clips or clamps
• Cerebrospinal fluid disorders
• Metal particles in the eyes
• Metal dental or articular prostheses
• Diffusion pomp or other infusion system
• Claustrophobia
• Head tattoo, make-up, hair gel
• Have any copper intrauterine device

Sponsors & Collaborators

• Hospices Civils de Lyon: lead

Study Sites (1)

Inserm U1028 Equipe Impact

Bron, 69676, France

Location

MeSH Terms

Interventions

Functional Neuroimaging

Intervention Hierarchy (Ancestors)

Neuroimaging; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Diagnostic Techniques, Neurological; Investigative Techniques

Study Officials

• Emiliano Macaluso, Prof.

  INSERM U1028 - Equipe ImpAct CRNL

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 8, 2019
• First Posted: March 13, 2019
• Study Start: July 5, 2019
• Primary Completion: July 5, 2019
• Study Completion: June 21, 2021
• Last Updated: January 11, 2022

Record last verified: 2022-01

Locations

FR (1)