Infections of the Central Nervous System

NCT03856528 | Withdrawn

• 1 other identifier: 2016-01244; me19Sutter2
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

This study is to describe the incidence of infectious meningitis and/or encephalitis, and to analyze clinical, diagnostic and treatment characteristics of patients with suspected (and subsequently verified and not verified) infection.

Conditions

Adult Patients With Suspected Meningitis and/or Encephalitis

Keywords

meningitis; encephalitis

Outcome Measures

Primary Outcomes (3)

• incidence of patients with suspected and confirmed ME (number)

  assessment of number of patients with suspected and confirmed ME

  single time point assessment during hospital stay (up to 4 weeks)

• Pathologic CT findings

  assessment of number of patients with pathologic CT findings

  single time point assessment during hospital stay (up to 4 weeks)

• Pathologic CT findings constituting a risk factor for herniation after performance of LP

  assessment of number of patients with pathologic CT findings constituting a risk factor for herniation after performance of LP

  single time point assessment during hospital stay (up to 4 weeks)

Secondary Outcomes (9)

• hematoma (number)

  single time point assessment during hospital stay (up to 4 weeks)

• Glasgow Outcome Score

  single time point assessment during hospital stay (up to 4 weeks)

• postpuncture headache (number)

  single time point assessment during hospital stay (up to 4 weeks)

• cerebral herniation (number)

  single time point assessment during hospital stay (up to 4 weeks)

• pathological CT findings (number)

  single time point assessment at hospitalisation (Day1)

Interventions

collection of patient data OTHER

Patient data will be obtained using digital patients records systems. The following data will be assessed: Demographics and baseline patient characteristics (e.g., gender, age, hospital admission and discharge dates), diagnoses, comorbidities (history of meningitis and/or encephalitis, epileptic disorders, remote stroke, remote intracranial bleeding, remote autoimmune disease, neurodegenerative disorders), laboratory features (blood cultures, lumbar puncture), features of neuroimaging (e.g., time admission-to-CT), therapeutic features (incl. time admission-to-treatment), Patients' outcome measures (Glasgow Outcome Score)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All patients admitted to the University Hospital Basel with suspected or confirmed infectious meningitis/encephalitis over a 10-year period (from January 2006 to December 2021).

You may qualify if:

• All patients aged ≥18 years admitted to the University Hospital Basel with confirmed infectious meningitis and/or encephalitis as principal and/or secondary diagnosis from January 2006 to December 2021 with or without cranial CT prior to LP
• All patients aged ≥18 years admitted to the University Hospital Basel over the same time period with suspected infectious meningitis and/or encephalitis as principal and/or secondary diagnosis with or without cranial CT

You may not qualify if:

• Patients without suspected infectious meningitis and/or encephalitis.
• Patients with the diagnosis of meningitis/encephalitis confirmed prior to hospital admission
• Patients who have refused "General Consent" (i.e., written agreement of patients which allows the further use of their collected medical data for research purposes in encoded form).

Sponsors & Collaborators

• University Hospital, Basel, Switzerland: lead

Study Sites (1)

Clinic for Intensive Care Medicine, University Hospital Basel

Basel, 4031, Switzerland

Location

Related Publications (1)

• Dittrich T, Marsch S, Egli A, Ruegg S, De Marchis GM, Tschudin-Sutter S, Sutter R. Predictors of infectious meningitis or encephalitis: the yield of cerebrospinal fluid in a cross-sectional study. BMC Infect Dis. 2020 Apr 23;20(1):304. doi: 10.1186/s12879-020-05022-6.

  PMID: 32326881 DERIVED

MeSH Terms

Conditions

Meningitis; Encephalitis

Condition Hierarchy (Ancestors)

Neuroinflammatory Diseases; Nervous System Diseases; Brain Diseases; Central Nervous System Diseases

Study Officials

• Raoul Sutter, PD Dr. med

  Clinic for Intensive Care Medicine, University Hospital Basel

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 26, 2019
• First Posted: February 27, 2019
• Study Start: March 1, 2019
• Primary Completion: December 31, 2024
• Study Completion: December 31, 2024
• Last Updated: February 19, 2025

Record last verified: 2025-02

Locations

CH (1)