Food & You: A Healthy Diet Through Algorithms

NCT03848299 | Completed

• 1 other identifier: 2017-02124
• Study Type: interventional
• Target: 1,782
• Locations: 1 country
• Sites: 1

Brief Summary

Food \& You is a large-scale citizen science research project in Switzerland. With this project, the researchers want to confirm that individuals respond differently to food, that is, that the blood sugar response (the level of sugar in the blood after a meal) varies among individuals, even after consumption of the same food or beverage. Secondly, the researchers want to develop an algorithm that will predict the individual blood sugar response and provide personalized diet recommendations.

Conditions

Food Habits

Keywords

Glycemic responses; Microbiota; Personalized nutrition; Digital cohort; Citizen Science

Outcome Measures

Primary Outcomes (1)

• Blood glucose level

  The participants will use the Flash Glucose Monitor FreeStyle Libre sensor and the FreeStyle Libre smartphone app from Abbott Diabetes Care to measure continuously during 14 days their glucose level.

  Two weeks

Secondary Outcomes (10)

• Dietary intake

  Two weeks

• Physical activity intensity

  Two weeks

• Physical activity frequency

  Two weeks

• Physical activity duration

  Two weeks

• The sleep duration

  Two weeks

Study Arms (1)

Experimental: Single Arm

EXPERIMENTAL

All participants will have to consume the same standardized breakfasts from the second to the seventh day, except the ones that are intolerant or allergic to lactose or/and gluten. In those cases, they will follow an adapted diet for their intolerance or allergies.

Other: Experimental: Single Arm

Interventions

Experimental: Single Arm OTHER

All participants will have to consume the same standardized breakfasts from the second to the seventh day, except the ones that are intolerant or allergic to lactose or/and gluten. In those cases, they will follow an adapted diet for their intolerance or allergies. Day 2 and 3: 110 g white bread. Day 4 and 5 : 110 g white bread and 30 g butter or 55 g white bread, 50 g dark chocolate for lactose intolerant. Day 6 and 7: Glucose drink (50g). The bread will be replaced by gluten-free bread for gluten intolerant participants.

Also known as: Standardized breakfasts consumption

Experimental: Single Arm

Eligibility Criteria

• Age: 18 Years+
• Gender Eligibility Details: 50% men, 50% women
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Men and women aged 18+.
• Have a postal address in Switzerland.
• Own a smartphone, minimum version iOS 10/Android 5.
• Sufficient knowledge of French, German or English to read and understand the instructions.
• Able to provide an informed consent.

You may not qualify if:

• Pregnancy.
• Persons on dialysis.
• Persons with chronic immunosuppressive medication usage.
• persons with skin disease, including contact dermatitis
• Critically-ill patients.
• Breastfeeding.
• Usage of antibiotics in the three months prior to enrollment.
• Chronically active inflammatory or neoplastic disease in the three years prior to enrollment.
• Chronic gastrointestinal disorder, including Inflammatory Bowel Disease and Celiac disease.
• Active neuropsychiatric disorder.
• Myocardial infarction or cerebrovascular accident in the six months prior to enrollment.
• Pre-diagnosed type I or type II diabetes mellitus.

Sponsors & Collaborators

• Ecole Polytechnique Fédérale de Lausanne: lead

Study Sites (1)

Epfl Sv Ghi Upsalathe1

Geneva, 1202, Switzerland

Location

Related Publications (1)

• Singh R, McDonald D, Hernandez AR, Song SJ, Bartko A, Knight R, Salathe M. Temporal nutrition analysis associates dietary regularity and quality with gut microbiome diversity: insights from the Food & You digital cohort. Nat Commun. 2025 Sep 30;16(1):8635. doi: 10.1038/s41467-025-63799-z.

  PMID: 41028733 DERIVED

MeSH Terms

Conditions

Feeding Behavior

Condition Hierarchy (Ancestors)

Behavior, Animal; Behavior

Study Officials

• Marcel Salathé, Pr

  Ecole Polytechnique Fédérale de Lausanne

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Model Details: The objective is to investigate the post-meal glucose response variations between individuals in function of their individual factors such as their microbiome composition or their lifestyle. All participants of the main cohort will have to follow a standardized diet during the first meal of the day from the second to the seventh day of the study participation. All participants will follow the same diet, except the ones that are intolerant or allergic to lactose or/and gluten. In those cases, they will follow an adapted diet for their intolerance or allergies.

Study Record Dates

• First Submitted: February 12, 2019
• First Posted: February 20, 2019
• Study Start: January 15, 2019
• Primary Completion: August 9, 2023
• Study Completion: December 18, 2023
• Last Updated: March 26, 2024

Record last verified: 2024-03

Data Sharing

• IPD Sharing: Will not share

Locations

CH (1)