Biomarkers of Acute Kidney Injury in Cardiac Surgery

NCT03830450 | Unknown

• 1 other identifier: University North
• Study Type: observational
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

Acute kidney injury (AKI) is the most common complication in patients after cardiac surgery. An usual estimation of risk for AKI is estimation of serum creatinine, which is unreliable indicator of AKI risk. Because of that, today different biomarkers are investigated to predict incidence for development AKI after cardiac surgery. This investigation will try to find potentially risk patients for developing AKI after cardiac surgery by using conventional markers (creatinine, glomerular filtration rate) in perioperative period comparing with two different biomarkers neutrophil gelatinase-associated lipocalin (NGAL) and growth differentiation factor 15 (GDF-15) which are proven markers in patients with increased risk for AKI development.

Conditions

Acute Kidney Injury (Nontraumatic)

Keywords

Acute kidney injury; Cardiac surgery; NGAL; GDF-15

Outcome Measures

Primary Outcomes (3)

• Consecutive values of neutrophil gelatinase-associated lipocalin (NGAL)

  By the changing of NGAL values in consecutive measuring, predict which patients are in increased risk for development of AKI

  One year

• Consecutive values of growth differentiation factor 15 (GDF-15)

  By the changing of GDF-15 values in consecutive measuring, predict which patients are in increased risk for development of AKI

  One year

• Consecutive values of glomerular filtration rate (GFR)

  By the changing of GFR values in consecutive measuring, predict which patients are in increased risk for development of AKI

  One Year

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients scheduled for cardiac surgery with usage of cardiopulmonary bypass

You may qualify if:

• patients scheduled for cardiac surgery (CABG, valve replacement/repair, combined)
• older than 18 years

You may not qualify if:

• previous known renal disease
• patients on chronic dialysis

Sponsors & Collaborators

• Nikola Bradic, MD: lead

MeSH Terms

Conditions

Acute Kidney Injury

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Central Study Contacts

Nikola Bradic, MD

CONTACT

+385 91 589 3480; nbradic@kbd.hr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: MD, Senior Lecturer

Study Record Dates

• First Submitted: February 2, 2019
• First Posted: February 5, 2019
• Study Start: December 1, 2020
• Primary Completion: December 31, 2022
• Study Completion: December 31, 2022
• Last Updated: November 13, 2020

Record last verified: 2020-11