Exploring the Relationship Among BNP, Fluid Status and Acute Kidney Injury in Critically Ill Patients

NCT02095275 | Unknown

• 1 other identifier: 201111012RIB
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

B-type natriuretic peptide (BNP) is rapidly released by the ventricles of the heart in response to myocardial stretch. This cardiac neurohormone is mostly elevated in patients with fluid overload or myocardium dysfunction. BNP is a very useful and important marker. It can predict mortality and cardiac events in patients in the ICU setting. In stable hemodialysis patients with normal LV function on echocardiography, high BNP levels are likely the result of blood volume expansion and require reduction in postdialysis dry weight. In the past, there were many methods to evaluate fluid status. Some are not reliable such as central venous pressure or physical examination. Some are invasive and expensive such as Swan Ganz、PiCCO catheter or bioimpedance device. Nevertheless, About the relationship between BNP and fluid status, a study found a significant relation between bioimpedance-derived body composition (BC) (fluid distribution) parameters and BNP concentrations. This relationship was independent of the cardiac history of the patient and suggests that the natriuretic peptide levels are to some degree modifiable by changing a patient's fluid distribution. In this study, the investigators want to observe that if the level of BNP can predict the occurrence of acute kidney injury and the need of renal replacement therapy. Besides, the investigators also want to see if BNP can be a useful and convenient marker to guide adjustment of optimal fluid status and then to improve outcome.

Conditions

Acute Kidney Injury (Nontraumatic)

Keywords

BNP, acute kidney injury, fluid status

Outcome Measures

Primary Outcomes (1)

• Change from Baseline in serum creatinine level at 3 months

  3 months

Secondary Outcomes (1)

• Mortality

  1 year

Study Arms (1)

Acute kidney injury

ICU patients with Acute kidney injury

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Critically ill patients in intensive care unit(older than 18 y/o)

You may qualify if:

• Patients \> 18 y/o in ICU

You may not qualify if:

• Acute coronary syndrome
• Congestive heart failure history
• Clinical pulmonary hypertension with various cause (iPAH, congenital heart disease, CTEPH, COPD with cor pulmonate,…)
• Patients with acute pulmonary embolism
• Chronic atrial fibrillation,
• Respiratory failure with high PEEP (\>10 CmH2)
• Terminal cancer patients
• Patients with Bosmina therapy
• Patients received CPR (IHCA or OHCA)

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital

Taipei, 100, Taiwan

RECRUITING

Biospecimen

Retention: SAMPLES WITHOUT DNA

Serum BNP

MeSH Terms

Conditions

Acute Kidney Injury

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Officials

• Yu-Hsiang Chou, bachelor

  National Taiwan University Hospital

  STUDY DIRECTOR

Central Study Contacts

yu-hsiang chou, bachelor

CONTACT

+886-2-23123456; chouyuhsiang@yahoo.com.tw

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 10, 2014
• First Posted: March 24, 2014
• Study Start: January 1, 2012
• Primary Completion: December 1, 2014
• Study Completion: December 1, 2014
• Last Updated: March 24, 2014

Record last verified: 2014-03

Locations

TW (1)