L-arginine Supplementation and Resistance Exercise

NCT03827005 | Completed

• 1 other identifier: HE16235
• Study Type: interventional
• Target: 30
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of this study was to examine the acute endothelial, cardiovascular, and performance responses to L-arginine by assessing flow-mediated dilation (FMD) and heart rate variability (HRV) both before and after resistance exercise to fatigue. Thirty (15 male, 15 female) physically active participants volunteered for a randomized, cross-over, double-blind, placebo- controlled clinical trial. Participants completed five sets of elbow extension-flexion exercise after consumption of either 3 g of placebo or 3 g L-arginine.

Conditions

Healthy Adult

Keywords

L-arginine; flow mediated dilation; resistance exercise

Outcome Measures

Primary Outcomes (2)

• Change in Flow mediated dilation 120 seconds post-cuff release

  Flow mediated dilation was measured using a A Philips HD11XE ultrasound system (Philips, Amsterdam, NL) equipped with 2D imaging, color and spectral Doppler, and a high-frequency vascular transducer.

  Change from Baseline and 120 seconds

• Change in Heart Rate Variability 10 minutes after intervention

  Hear rate variability was recorded using a Polar H7 Bluetooth strap (Polar, Bethpage, NY) combined Personal Pro Elite HRV smartphone application (elitehrv.com) over 5 minutes intervals then further analyzed with Kubios software

  Change from Baseline and 10 minutes post-exercise

Study Arms (2)

placebo

PLACEBO COMPARATOR

3 grams cornstarch once per day for one day.

Dietary Supplement: L-arginine; Dietary Supplement: Placebo

L-arginine

EXPERIMENTAL

3 g L-arginine once per day for one day.

Dietary Supplement: L-arginine; Dietary Supplement: Placebo

Interventions

L-arginine DIETARY_SUPPLEMENT

NOW Foods, Bloomingdale, IL

L-arginine; placebo

Placebo DIETARY_SUPPLEMENT

InHealth Specialty Pharmacy, Fargo, ND

Also known as: cornstarch

L-arginine; placebo

Eligibility Criteria

• Age: 18 Years - 25 Years
• Gender Eligibility Details: self reported
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• generally healthy
• physically active

You may not qualify if:

• previous clinical trial
• pregnancy

Sponsors & Collaborators

• North Dakota State University: lead

Related Publications (7)

• Alvares TS, Conte CA, Paschoalin VM, Silva JT, Meirelles Cde M, Bhambhani YN, Gomes PS. Acute l-arginine supplementation increases muscle blood volume but not strength performance. Appl Physiol Nutr Metab. 2012 Feb;37(1):115-26. doi: 10.1139/h11-144. Epub 2012 Jan 17.

  PMID: 22251130 BACKGROUND

• Alvares TS, Meirelles CM, Bhambhani YN, Paschoalin VM, Gomes PS. L-Arginine as a potential ergogenic aid in healthy subjects. Sports Med. 2011 Mar 1;41(3):233-48. doi: 10.2165/11538590-000000000-00000.

  PMID: 21395365 BACKGROUND

• Bondonno CP, Croft KD, Hodgson JM. Dietary Nitrate, Nitric Oxide, and Cardiovascular Health. Crit Rev Food Sci Nutr. 2016 Sep 9;56(12):2036-52. doi: 10.1080/10408398.2013.811212.

  PMID: 25976309 BACKGROUND

• Bai Y, Sun L, Yang T, Sun K, Chen J, Hui R. Increase in fasting vascular endothelial function after short-term oral L-arginine is effective when baseline flow-mediated dilation is low: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 2009 Jan;89(1):77-84. doi: 10.3945/ajcn.2008.26544. Epub 2008 Dec 3.

  PMID: 19056561 BACKGROUND

• Kapadia MR, Eng JW, Jiang Q, Stoyanovsky DA, Kibbe MR. Nitric oxide regulates the 26S proteasome in vascular smooth muscle cells. Nitric Oxide. 2009 Jun;20(4):279-88. doi: 10.1016/j.niox.2009.02.005. Epub 2009 Feb 20.

  PMID: 19233305 BACKGROUND

• Arnal JF, Dinh-Xuan AT, Pueyo M, Darblade B, Rami J. Endothelium-derived nitric oxide and vascular physiology and pathology. Cell Mol Life Sci. 1999 Jul;55(8-9):1078-87. doi: 10.1007/s000180050358.

  PMID: 10442089 BACKGROUND

• Fahs CA, Heffernan KS, Fernhall B. Hemodynamic and vascular response to resistance exercise with L-arginine. Med Sci Sports Exerc. 2009 Apr;41(4):773-9. doi: 10.1249/MSS.0b013e3181909d9d.

  PMID: 19276857 BACKGROUND

MeSH Terms

Interventions

Arginine; Starch

Intervention Hierarchy (Ancestors)

Amino Acids, Basic; Amino Acids; Amino Acids, Peptides, and Proteins; Amino Acids, Diamino; Amino Acids, Essential; Glucans; Biopolymers; Polymers; Macromolecular Substances; Dietary Carbohydrates; Carbohydrates; Polysaccharides

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: blinding performed by co-investigator not involved with data collection
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Model Details: double blind, placebo, controlled -cross over

Study Record Dates

• First Submitted: July 1, 2018
• First Posted: February 1, 2019
• Study Start: July 16, 2016
• Primary Completion: April 30, 2017
• Study Completion: May 30, 2017
• Last Updated: February 1, 2019

Record last verified: 2019-01

Data Sharing

• IPD Sharing: Will not share