Thoracic Surgery Oncology Group (TSOG) Protocol: Registry Trial of Active Surveillance for Multifocal Ground Glass Opacities (GGOs)
Sponsor study identifier
observational
338
2 countries
32
Study Start
January 9, 2019
Actual (reported)Primary Completion
January 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
January 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
The purpose of this registry study is to actively monitor people with GGOs and collect information about them, so that investigators can learn more about these lesions and about the risk of developing lung cancer in study participants whose GGOs are being monitored in the active surveillance program.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
January 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 9, 2019
Actual (reported)January 9, 2019
Actual (reported)January 14, 2019
Actual (reported)January 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
January 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
lung cancer-specific survival
5 years
Patients with GGOs or mixed subsolid pulmonary nodules may be recruited from participating Thoracic Oncology Surgical Group (TSOG) sites, in accordance with local institutional practice and referral patterns, and assessed for eligibility based on the criteria listed below.
University of California San Diego
San Diego, California, 92103, United States
Stanford University Medical Center (Data collection only)
Stanford, California, 94305-5408, United States
Hartford Healthcare
Hartford, Connecticut, 06102, United States
Rush University Medical Center (Data collection only)
Chicago, Illinois, 606012, United States
Massachusetts General Hospital Cancer Center
Boston, Massachusetts, 02114, United States
Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States
University of Michigan
Huang J, Tan KS, Altorki N, Antonoff M, Blackmon S, Bueno R, Burt B, Demmy T, Evans N, Donahoe L, Harpole D, Jarrar D, Kozower B, Lanuti M, Liberman M, Lin J, Liou D, Liptay M, Luketich J, Pennathur A, Petersen G, Ripley R, Rochefort M, Seder CW, Shrager J, Su S, Tong B, Shargall Y, Vaporciyan A, Waddell T, Weksler B, Wigle D, Yendamuri S, Jones DR. Initial patient characteristics of Thoracic Surgical Oncology Group 102: A multicenter prospective registry of active surveillance in patients with multiple ground-glass opacities. J Thorac Cardiovasc Surg. 2025 Apr;169(4):1100-1107. doi: 10.1016/j.jtcvs.2024.09.054. Epub 2024 Oct 10.
James Huang, MD
Memorial Sloan Kettering Cancer Center
338 participants (actual enrollment reported by the registry).
First Submitted
January 9, 2019
First Posted
January 14, 2019
Study Start
January 9, 2019
Actual (reported)Contact the study team to confirm eligibility.
Ann Arbor, Michigan, 48109, United States
Mayo Clinic
Rochester, Minnesota, 55905, United States
George Washington University School of Medicine
St Louis, Missouri, 63110, United States
Washington University School of Medicine
St Louis, Missouri, 63110, United States
Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Monmouth
Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Bergen
Montvale, New Jersey, 07645, United States
Roswell Park Cancer Institute (Data Collection Only)
Buffalo, New York, 14263-0001, United States
Memorial Sloan Kettering Commack
Commack, New York, 11725, United States
Memorial Sloan Kettering Westchester
Harrison, New York, 10604, United States
Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
New York Presbyterian Hospital
New York, New York, 10065, United States
Memorial Sloan Kettering Nassau
Uniondale, New York, 11553, United States
Duke University Medical Center
Durham, North Carolina, 27701, United States
Lehigh Valley Health Network
Allentown, Pennsylvania, 18103, United States
University of Pennsylvania (Data Collection Only)
Philadelphia, Pennsylvania, 19104, United States
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, 19107, United States
Fox Chase Cancer Center
Philadelphia, Pennsylvania, 19111, United States
Temple University
Philadelphia, Pennsylvania, 19140, United States
Allegheny Health Network
Pittsburgh, Pennsylvania, 15212, United States
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, 15213, United States
MD Anderson Cancer Center
Houston, Texas, 77030-4009, United States
Baylor University Medical Center
Houston, Texas, 77030, United States
McMaster University (Data Collection Only)
Hamilton, Ontario, L8N 3Z5, Canada
University Health Network
Toronto, Ontario, M5G 2C4, Canada
Centre Hospitalier de l'Université de Montreal
Montreal, Quebec, H2L 4M1, Canada
Primary Completion
January 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
January 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
October 23, 2026
Record last verified: 2026-10
Memorial Sloan Kettering Cancer Center supports the international committee of medical journal editors (ICMJE) and the ethical obligation of responsible sharing of data from clinical trials. The protocol summary, a statistical summary, and informed consent form will be made available on clinicaltrials.gov when required as a condition of Federal awards, other agreements supporting the research and/or as otherwise required. Requests for deidentified individual participant data can be made following one year after publication and for up to 36 months later. Deidentified individual participant data reported in the manuscript will be shared under the terms of a Data Use Agreement and may only be used for approved proposals. Requests may be made to: crdatashare@mskcc.org.
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Source: ClinicalTrials.gov.
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