Exercise and Overnight Motor Sequence Task

NCT03800368 | Completed

• 1 other identifier: HKU_Psych
• Study Type: interventional
• Target: 51
• Locations: 0 countries
• Sites: N/A

Brief Summary

The objective of this randomized controlled trial (RCT) is to compare the changes of the sleep-related memory functions in patients with psychosis after they have completed the 12-week high-intensity exercise intervention, the 12-week low-intensity exercise intervention, or the 12-week controlled non-exercise intervention respectively. Fifty-one patients with psychosis, patients who received either the high-intensity exercise or low-intensity exercise as intervention shown a significant improvement to their impaired sleep-related memory function, while those who received non-exercise intervention has no such improvement. Moreover, high-intensity exercise may have a more prominent effect compare to low-intensity exercise.

Conditions

Schizophrenia and Related Disorders; Psychotic Disorders

Keywords

Exercise; Sleep-dependent memory consolidation; Aerobic; Anaerobic

Outcome Measures

Primary Outcomes (1)

• The sleep-dependent procedural memory consolidation after 12 weeks of intervention

  Tested by comparing the finger-tapping motor sequence task performance between the three groups during the 12-week follow-up assessment.

  12-week Follow-up

Secondary Outcomes (4)

• The verbal memory consolidation after 12 weeks of intervention

  12-week Follow-up

• The attention performance after 12 weeks of intervention

  12-week Follow-up

• The sleep quality after 12 weeks of intervention

  12-week Follow-up

• The insomnia severity after 12 weeks of intervention

  12-week Follow-up

Study Arms (3)

High-endurance group

EXPERIMENTAL

This group of subjects will receive 2-3 sessions of high-intensity cycling exercise training per week, for a total of 12 weeks. The exercise the subjects received will interchange between the aerobic and anaerobic state.

Other: Exercise

Low-endurance group

EXPERIMENTAL

This group of subjects will receive 2-3 sessions of low-intensity cycling exercise training per week, for a total of 12 weeks. The exercise the subjects received will maintain at an aerobic level.

Other: Exercise

Psycho-education

ACTIVE COMPARATOR

This group of subjects will receive 2-3 sessions of psycho-education class per week, for a total of 12 weeks. The content of the class includes non-exercise related psycho-education content to participants (e.g., food hygiene, psychological well being, food nutrition, etc).

Other: Non-exercise

Interventions

Exercise OTHER

Indoor cycling exercise intervention

High-endurance group; Low-endurance group

Non-exercise OTHER

Psycho-education

Psycho-education

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Aged from 18 to 55
• Based on the SCID diagnosed to have schizophrenia and related psychotic disorders
• Ability to understand the nature of the study and to give written informed consent

You may not qualify if:

• Severe physical illness (Myocardial Infarction, Hypertension, Fracture, Spinal problems in which exercise may be contraindicated), and seizure disorders
• Comorbid substance dependence
• Unstable psychotic symptoms
• A history of brain trauma or organic brain disease
• Known history of intellectual disability or special school attendance
• Answered one or more "yes" in the PAR-Q and without doctors approval for exercise

Sponsors & Collaborators

• The University of Hong Kong: lead

Related Publications (1)

• Lo LLH, Lee EHM, Hui CLM, Chong CSY, Chang WC, Chan SKW, Lin JJ, Lo WTL, Chen EYH. Effect of high-endurance exercise intervention on sleep-dependent procedural memory consolidation in individuals with schizophrenia: a randomized controlled trial. Psychol Med. 2023 Apr;53(5):1708-1720. doi: 10.1017/S0033291721003196. Epub 2021 Oct 7.

  PMID: 34615565 DERIVED

MeSH Terms

Conditions

Schizophrenia; Psychotic Disorders; Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders; Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Lik Hang Lincoln Lo

  The University of Hong Kong

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Postdoctoral Fellow

Study Record Dates

• First Submitted: January 3, 2019
• First Posted: January 11, 2019
• Study Start: December 21, 2016
• Primary Completion: September 1, 2017
• Study Completion: September 1, 2017
• Last Updated: January 11, 2019

Record last verified: 2019-01

Data Sharing

• IPD Sharing: Will not share