Muscle Architecture of Lower Extremity In Multiple Sclerosis

NCT03766698 | Completed

• 1 other identifier: SankoUniversity
• Study Type: observational
• Target: 35
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study was to determine the muscle architecture of the lower extremity muscles (pennation angle, muscle fiber length and muscle thickness) in patients with multiple sclerosis. Lower extremity muscles of patients with multiple sclerosis and healthy individuals; rectus femoris, biceps femoris, tibialis anterior, gastrosoleus and gastrocnemius muscles will be examined by ultrasound method.

Conditions

Multiple Sclerosis

Keywords

Multiple Sclerosis; Muscle Architecture; Lower extremity

Outcome Measures

Primary Outcomes (3)

• Muscle Architecture Pennation Angle

  Pennation Angle will be assesed by ultrasound imaging.

  The evaluation will be made on the first 1 day.

• Muscle Architecture Muscle Fiber Lengh

  Muscle Fiber Lenght will be assesed by ultrasound imaging.

  The evaluation will be made on the first 1 day.

• Muscle Architecture Muscle Thickness

  Muscle Thickness will be assesed by ultrasound imaging.

  The evaluation will be made on the first 1 day.

Secondary Outcomes (3)

• Muscle Strength

  The evaluation will be made on the first 1 day.

• Circumference Measurement of Thigh

  The evaluation will be made on the first 1 day.

• Circumference Measurement of shin

  The evaluation will be made on the first 1 day.

Other Outcomes (2)

• Thickness of subcutaneous fat from anterior thigh

  The evaluation will be made on the first 1 day.

• Thickness of subcutaneous fat from posterior leg

  The evaluation will be made on the first 1 day.

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Study Population consists of Multiple Sclerosis Patients and Healthy Volunteers.

You may qualify if:

• years old
• Individuals who agree to be voluntary,
• With the EDSS 4 and below
• Without pregnancy
• Do not receive corticosteroid treatment in the last month
• Do not take any medicine that will affect walking in the last 1 month

You may not qualify if:

• Those who refuse to volunteer,
• EDSS over 4
• Pregnancy
• Corticosteroid therapy within 1 month
• Any medication that will affect walking in the last 1 month

Sponsors & Collaborators

• Sanko University: lead

Study Sites (1)

Sanko University

Gaziantep, Turkey (Türkiye)

Location

Related Publications (2)

• Wens I, Dalgas U, Vandenabeele F, Krekels M, Grevendonk L, Eijnde BO. Multiple sclerosis affects skeletal muscle characteristics. PLoS One. 2014 Sep 29;9(9):e108158. doi: 10.1371/journal.pone.0108158. eCollection 2014.

  PMID: 25264868 RESULT

• Kirmaci ZIK, Firat T, Ozkur HA, Neyal AM, Neyal A, Ergun N. Muscle architecture and its relationship with lower extremity muscle strength in multiple sclerosis. Acta Neurol Belg. 2022 Dec;122(6):1521-1528. doi: 10.1007/s13760-021-01768-1. Epub 2021 Aug 20.

  PMID: 34417688 DERIVED

Related Links

• Multiple Sclerosis and Skeletal Muscle

MeSH Terms

Conditions

Multiple Sclerosis

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases

Study Officials

• Zekiye İpek Katırcı Kırmacı

  Sanko University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: December 4, 2018
• First Posted: December 6, 2018
• Study Start: December 18, 2018
• Primary Completion: January 18, 2020
• Study Completion: February 15, 2020
• Last Updated: March 18, 2020

Record last verified: 2020-03

Locations

TU (1)