Yoga in Multiple Sclerosis Patients

NCT07155642 | Completed

• 1 other identifier: IRU-FTR-NO-02
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Objective The objective of this study will be to compare the effects of an eight-week Yin-based yoga program and conventional physiotherapy on fatigue, balance, gait, and quality of life in individuals with Multiple Sclerosis (MS). Methods Twenty patients with MS will be randomly assigned to either a yoga group (n = 10) or a physiotherapy group (n = 10). Both groups will participate in supervised sessions lasting 60 minutes per day, three days per week, over an eight-week period. The yoga intervention will be Yin-based, incorporating centering, yoga postures, breathing exercises, and relaxation. The physiotherapy program will consist of aerobic training, strengthening and spinal stabilization exercises, balance and coordination activities, and stretching. Outcome measures will include the Fatigue Severity Scale (FSS) for fatigue, the Berg Balance Scale (BBS) for balance, the 12-item Multiple Sclerosis Walking Scale (MSWS-12) for gait, and the Multiple Sclerosis Quality of Life Questionnaire (MSQOL-54) for physical and mental health-related quality of life.

Conditions

Multiple Sclerosis

Keywords

multiple sclerosis; yoga; fatigue; balance; quality of life

Outcome Measures

Primary Outcomes (2)

• MS Walking Scale (MSWS-12)

  The MSWS-12 is a 12-item self-reported questionnaire that assesses the impact of MS on walking ability over the past two weeks. Items are rated on a 5-point scale (1: almost never, 5: extremely). Higher scores indicate greater perceived walking limitations or difficulties

  3 months

• MS Quality of Life-54 (MSQOL-54)

  The MSQOL-54 is a disease-specific quality of life questionnaire for MS patients. It comprises 31 questions divided into three sub-dimensions: psychological, physical, and psychosocial quality of life. Lower scores indicate a higher quality of life

  3 months

Secondary Outcomes (2)

• Fatigue Severity Scale (FSS)

  3 months

• Berg Balance Scale (BBS)

  3 months

Study Arms (2)

yoga

EXPERIMENTAL

Participants in the yoga group received a total of 8 weeks of intervention, conducted 3 days a week, for 60 minutes per day. The program components were: * 8 minutes of meditation practice. * 40 minutes of Yin and Yang yoga postures. (It's highly recommended to briefly explain what "Yin and Yang yoga postures" specifically entail in the full paper's methodology section, e.g., "Yin yoga focuses on holding passive poses for longer durations to target deep connective tissues, while Yang yoga incorporates more active, flowing sequences to build strength and flexibility.") * 2 minutes of breathing exercises (pranayama). * 10 minutes of deep relaxation (savasana).

Other: yoga

Conventional Physiotherapy

ACTIVE COMPARATOR

Participants in the conventional physiotherapy group also underwent an 8-week program, 3 days a week, for 60 minutes per day. This program included: * Aerobic exercises. * Stretching exercises. * Strengthening exercises. * Spinal stabilization exercises. * Balance exercises.

Other: conventional physiotheraphy

Interventions

yoga OTHER

Participants in the yoga group received a total of 8 weeks of intervention, conducted 3 days a week, for 60 minutes per day. The program components were: • 8 minutes of meditation practice. • 40 minutes of Yin and Yang yoga postures. (It's highly recommended to briefly explain what "Yin and Yang yoga postures" specifically entail in the full paper's methodology section, e.g., "Yin yoga focuses on holding passive poses for longer durations to target deep connective tissues, while Yang yoga incorporates more active, flowing sequences to build strength and flexibility.") • 2 minutes of breathing exercises (pranayama). • 10 minutes of deep relaxation (savasana).

yoga

conventional physiotheraphy OTHER

Participants in the conventional physiotherapy group also underwent an 8-week program, 3 days a week, for 60 minutes per day. This program included: * Aerobic exercises. * Stretching exercises. * Strengthening exercises. * Spinal stabilization exercises. * Balance exercises.

Conventional Physiotherapy

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Being between 18-65 years of age.
• Voluntarily giving informed consent to participate in the study.
• Having either Relapsing-Remitting MS (RRMS) or Secondary Progressive MS (SPMS) type.
• An Expanded Disability Status Scale (EDSS) score of 5.5 or below.
• No MS exacerbation within the last 4 weeks.
• Possessing the willingness, ability, and cognitive intactness to participate in the interventions.

You may not qualify if:

• Using medication specifically for fatigue.
• Presence of major sleep disorders, clinical depression, hypothyroidism, or B12 deficiency.
• Severe balance problems (e.g., Central Vestibular Disorders (CVO), peripheral neuropathy, Meniere's disease, vertigo).
• Having received corticosteroid treatment within the last 4 weeks.
• Pregnancy.
• Serious cardiovascular disease, hypertension, or orthopedic limitations.
• Presence of Carpal Tunnel Syndrome.

Sponsors & Collaborators

• Istanbul Rumeli University: lead

Study Sites (1)

Öziri

Ataşehir, Istanbul, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Multiple Sclerosis; Fatigue

Interventions

Yoga

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Mind-Body Therapies; Complementary Therapies; Therapeutics; Spiritual Therapies; Exercise Movement Techniques; Physical Therapy Modalities

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD

Study Record Dates

• First Submitted: August 24, 2025
• First Posted: September 4, 2025
• Study Start: March 4, 2019
• Primary Completion: April 20, 2019
• Study Completion: June 7, 2019
• Last Updated: September 4, 2025

Record last verified: 2025-08

Locations

TU (1)