The Role of Cognitive Function and Electroencephalography on Acute and Chronic Pain After Surgery

NCT03761576 | Unknown

• 1 other identifier: 2018PHB191-02
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The project will apply the methods of clinical observation experiment, (1) to collect the cognitive function data preoperatively and early postoperatively, as well as the pain score data at multiple time points pre- and postoperatively, and to observe the role of the degree of recovery of early postoperative cognitive function on acute pain and chronic pain after surgery. (2) to collect the resting-state electroencephalography (EEG) preoperatively, and to assess the role of EEG index system on the prediction of the degree of recovery of early postoperative cognitive function as well as the acute pain and chronic pain after surgery.

Conditions

Acute Pain; Chronic Pain; Thoracic Surgery; Electroencephalography; Brain Mechanism

Outcome Measures

Primary Outcomes (2)

• acute pain

  numerical rating scale(NRS)\>3

  the third day of the surgery

• chronic pain

  numerical rating scale(NRS)\>3

  the second month of the surgery

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

100

You may qualify if:

• surgery were planned to be performed under general anesthesia
• Educational attainment beyond high school
• Require postoperative analgesia and sign the informed consent

You may not qualify if:

• with mental illness or a family history of mental illness
• Patients with cerebrovascular diseases or cerebrovascular accidents
• Previous head trauma history or craniotomy
• Using central analgesics, opioids addiction
• With a history of alcoholism
• do not understand the numerical rating scale(NRS) score and can not use patient-controlled analgesia(PCA）

Sponsors & Collaborators

• Yi Feng, MD: lead

Study Sites (1)

Peking University People's Hospital

Beijing, Beijing Municipality, 100044, China

Location

Related Publications (2)

• Zhang YQ, Li YR, Han Q, Gao F, Feng Y. Evaluation of dynamic brain function in patients with different degrees of chronic pain by EEG microstate analysis. BMC Anesthesiol. 2025 Oct 14;25(1):491. doi: 10.1186/s12871-025-03326-1.

  PMID: 41087907 DERIVED

• Han Q, Yue L, Gao F, Zhang L, Hu L, Feng Y. The Prediction of Acute Postoperative Pain Based on Neural Oscillations Measured before the Surgery. Neural Plast. 2021 Apr 9;2021:5543974. doi: 10.1155/2021/5543974. eCollection 2021.

  PMID: 33897775 DERIVED

MeSH Terms

Conditions

Acute Pain; Chronic Pain

Condition Hierarchy (Ancestors)

Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Yi Feng, MD

  Peking University People's Hospital

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: director of department of anesthesiology and painmanagement

Study Record Dates

• First Submitted: November 30, 2018
• First Posted: December 3, 2018
• Study Start: December 21, 2018
• Primary Completion: March 31, 2021
• Study Completion: October 31, 2023
• Last Updated: October 18, 2022

Record last verified: 2022-10

Locations

CN (1)