Changes of Regional Tissue Oxygenation Saturation After Successful Femoral Nerve Block

NCT03753594 | Completed

• 1 other identifier: XH20181118
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Regional tissue oxygenation saturation has been shown to increase in innervated regions after sympathetic block. The aim of this prospective observational study was to evaluate the changes of regional tissue oxygenation saturation by near-infrared spectroscopy after successful femoral nerve block with ropivacaine and determine whether the changes of regional tissue oxygenation saturation can be affected by the concentration of ropivacaine.

Conditions

Anesthesia, Local

Keywords

Peripheral nerve block

Outcome Measures

Primary Outcomes (1)

• Regional tissue oxygenation saturation after successful femoral nerve block

  rSO2

  at 5-minute intervals till 30 minutes after regional block

Secondary Outcomes (1)

• Pinprick sensory scores

  5 minute before regional block and at 5-minute intervals till 30 minutes after regional block

Study Arms (2)

H group

Patients scheduled for elective knee arthroscopy with peripheral nerve block will receive ultrasound-guided femoral nerve block with 0.5% ropivacaine. Regional tissue oxygenation saturation of the nerve innervation area and pinprick sensory tests at 5 min were assessed before the block and at 5-min intervals till 30 min after the block.

Device: tissue oxygenation saturation

L group

Patients scheduled for elective knee arthroscopy with peripheral nerve block will receive ultrasound-guided femoral nerve block with 0.25% ropivacaine. Regional tissue oxygenation saturation of the nerve innervation area and pinprick sensory tests were assessed at 5 min before the block and at 5-min intervals till 30 min after the block.

Device: tissue oxygenation saturation

Interventions

tissue oxygenation saturation DEVICE

tissue oxygenation saturation

H group; L group

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

One hundred adult patients scheduled for elective knee arthroscopy with peripheral nerve block

You may qualify if:

• Informed consent
• American Society of Anesthesiologists physical statusⅠ-Ⅱ
• Undergo elective elective knee arthroscopy with peripheral nerve block

You may not qualify if:

• Refusal to participate in the study
• BMI\>35
• Any contraindications to peripheral nerve block such as coagulation abnormalities, •Allergy to local anaesthetics, peripheral neuropathy

Sponsors & Collaborators

• Huazhong University of Science and Technology: lead

Study Sites (1)

Union Hospital

Wuhan, Hubei, China

Location

Study Officials

• Xiangdong Chen, Doctor

  Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator, Department of Anesthesiology, Union Hospital of Tongji Medical College

Study Record Dates

• First Submitted: November 20, 2018
• First Posted: November 27, 2018
• Study Start: November 30, 2018
• Primary Completion: May 10, 2019
• Study Completion: May 10, 2019
• Last Updated: May 13, 2019

Record last verified: 2019-05

Locations

CN (1)